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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 14A
PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE
SECURITIES EXCHANGE ACT OF 1934
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Definitive Additional Materials
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Soliciting Material Pursuant to sec. 240.14a-11(c) or sec. 240.14a-12§240.14a-12
SEELOS THERAPEUTICS, INC.
APRICUS BIOSCIENCES, INC.
(Name of Registrant as Specified In Its Charter)
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Fee computed on table belowin exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11.
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SEELOS THERAPEUTICS, INC.


300 Park Avenue, 2nd Floor
APRICUS BIOSCIENCES, INC.
11975 El Camino Real, Suite 300
San Diego, California 92130New York, NY 10022
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
To Be Held on May 20, 2016
2022
Dear Stockholder:
You are cordially invited to attend the Annual Meeting of Stockholders (the “Annual Meeting”) of Apricus Biosciences,Seelos Therapeutics, Inc., a Nevada corporation (the “Company”). The Annual Meeting will be held virtually, via live webcast at www.virtualshareholdermeeting.com/SEEL2022, on Friday, May 20, 20162022 at 8:00 a.m., local time, at Latham & Watkins LLP, located at 12670 High Bluff Drive, San Diego, California 92130,Eastern Time, for the following purposes:
(1)
To elect threeone Class I directors,director, nominated by our Board of Directors, to serve until our 2019 Annual Meeting2025 annual meeting of Stockholdersstockholders and until their successors arehis successor is duly elected and qualified;qualified (Proposal No. 1);
(2)
To ratify the selection of BDO USA,KPMG LLP (“BDOKPMG”) as our independent registered public accounting firm for the fiscal year ending December 31, 2016;2022 (Proposal No. 2);
(3)
To conduct an advisory (non-binding) vote on executive compensation;compensation (Proposal No. 3); and
(4)
To transact such other business as may properly come before the Annual Meeting or any adjournment(s) thereof.
The record dateRecord Date for the Annual Meeting is March 24, 2016.25, 2022. Only stockholders of record at the close of business on that date may vote at the meeting or any adjournment(s) or postponement(s) thereof. The accompanying Proxy Statement more fully describes the details of the business to be conducted at the Annual Meeting. Our proxy materials (which include the Proxy Statement attached to this notice, our most recent Annual Report on Form 10-K and form of proxy card) are also available to you via the Internet at www.proxyvote.com.
By Order of the Board of Directors,
 

Richard W. Pascoe
Secretary
April 19, 2016
San Diego, California
Raj Mehra, Ph.D.
Chief Executive Officer
April 12, 2022
New York, New York
THE BOARD OF DIRECTORS APPRECIATES AND ENCOURAGES YOUR PARTICIPATION IN THE ANNUAL MEETING. WHETHER OR NOT YOU EXPECT TO ATTEND THE ANNUAL MEETING, IT IS IMPORTANT THAT YOUR SHARES BE REPRESENTED. ACCORDINGLY, PLEASE VOTE YOUR PROXY VIA THE INTERNET AT WWW.PROXYVOTE.COM OR OVER THE TELEPHONE AT 1-800-690-6903 OR SIGN, DATE AND PROMPTLY RETURN THE ENCLOSED PROXY CARD BY MAIL IN THE PRE-PAID ENVELOPE PROVIDED. EVEN IF YOU HAVE VOTED BY PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTENDYOUR SHARES ELECTRONICALLY DURING THE ANNUAL MEETING.
Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:

The Notice, Proxy Statement, Proxy Card and Form 10-K are available at www.proxyvote.com.

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SEELOS THERAPEUTICS, INC.


300 Park Avenue, 2nd Floor
APRICUS BIOSCIENCES, INC.
11975 El Camino Real, Suite 300
San Diego, California 92130
New York, New York 10022
PROXY STATEMENT
General Information
This Proxy Statement (the “Proxy Statement”) is furnished in connection with the solicitation of proxies by the Board of Directors (the “Board”) of Apricus Biosciences,Seelos Therapeutics, Inc. (the(“we”,us”, “our”, the “Company” or “Seelos”) for use at the Company’s Annual Meeting of Stockholders (the “Annual Meeting”) to be held virtually, via live webcast at www.virtualshareholdermeeting.com/SEEL2022, on Friday, May 20, 2016,2022, at 8:00 a.m., localEastern time, at Latham & Watkins LLP, located at 12670 High Bluff Drive, San Diego, California 92130, and any adjournment(s) or postponement(s) thereof. This proxy statementProxy Statement is being mailed on or about April 21, 201615, 2022 to the stockholders of record of the Company’s common stock, par value $0.001 per share (the “Common Stock”), as of March 24, 201625, 2022 (the “Record Date”). This year’s Annual Meeting will be conducted solely online via live webcast. You will be able to attend and participate in the Annual Meeting online, vote your shares electronically and submit your questions prior to and during the meeting by visiting www.virtualshareholdermeeting.com/SEEL2022 on Friday, May 20, 2022, at 8:00 a.m., Eastern time. To be admitted to the Annual Meeting at www.virtualshareholdermeeting.com/SEEL2022, you must enter the control number included in your proxy materials. There is no physical location for the Annual Meeting. We recommend you log in at least 15 minutes before the meeting to ensure you are logged in when the meeting starts. Further instructions on how to attend and participate online are available at www.virtualshareholdermeeting.com/SEEL2022. If you encounter any difficulties accessing the virtual meeting during the check-in or meeting time, please call the technical support number that will be posted on the log-in page at www.virtualshareholdermeeting.com/SEEL2022.
Solicitation and Voting Procedures
The solicitation of proxies will be conducted by mail and the Company will bear all costs. These costs will include the expense of preparing and mailing proxy materials for the Annual Meeting and reimbursements paid to brokerage firms and others for their expenses incurred in forwarding solicitation material regarding the Annual Meeting to “Beneficial Holders(defined(as defined below). The Company has engaged a proxy solicitation firm, Morrow & Co.,Sodali LLC, 470 West Ave, Stamford, CT 06902, and may conduct further solicitation personally, by telephone or by facsimile with the assistances of our officers, directors and regular employees, none of whom will receive additional compensation for assisting with the solicitation. The Company expects that the out-of-pocket costs associated with solicitation of proxies will be approximately $5,000.$9,500.
As of the Record Date, there were 61,778,121105,590,773 shares of the Company’s common stock, par value $.001 per share (the “Common Stock”) issued and outstanding. Only holders of record of Common Stock at the close of business on the Record Date are entitled to notice of and to vote at the Annual Meeting. Each share of Common Stock outstanding on the Record Date is entitled to one vote on all matters.
Holders of record who hold shares of Common Stock directly on the Record Date must return a proxy by one of the methods described on the proxy card or attend the Annual Meeting in personvirtually in order to vote on the proposals. Investors who hold shares of Common Stock indirectly on the Record Date (“Beneficial Holders”) through a brokerage firm, bank or other financial institution (a “Financial Institution”) must return a voting instruction form to have their shares voted in accordance with their instructions. Financial Institutions have discretion to vote absent instructions with respect to certain routine matters, such as Proposal No. 2, the ratification of the independent registered public accounting firm, but not with respect to matters that are
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considered non-routine, such as ProposalsProposal Nos. 1 and 3, the election of directorsa director and the advisory vote on executive compensation, respectively. A “Broker Non-Vote” occurs when a Financial Institution has not received instructions from the beneficial owner and does not have discretionary authority to vote the shares for these non-routine matters.
The presence, in personvirtually or by proxy, of a majority of the outstanding shares of Common Stock on the Record Date, will constitute a quorum for the transaction of business at the Annual Meeting and any adjournments thereof. Abstentions from voting on a proposal and Broker Non-Votes will count for purposes of determining a quorum, but will not be counted as votes cast on any proposal.cast. A description of the required vote for each proposal is included within each proposal below.
We urge any stockholder not planning to attend the Annual Meeting to vote their proxy in advance, whether via the Internet (www.proxyvote.com) or by telephone (1-800-690-6903) or by mailing an executed proxy card to us. The deadline to vote by Internet or by telephone is 11:59 P.M. Eastern Time on Thursday, May 19, 2016.2022.
Any holder of record may revoke a proxy submitted in advance of the Annual Meeting by: (i) delivering a written revocation to the Company’s Secretary before the Annual Meeting, (ii) delivering an executed, later-dated proxy or (iii) votingparticipating in person at the Annual Meeting.


Meeting and voting shares electronically during the meeting.
Beneficial Holders who wish to change or revoke their voting instructions should contact their Financial InstitutionInstitutions for information on how to do so. Beneficial Holders who wish to attend the Annual Meeting and vote in personelectronically during the meeting should contact their respective Financial InstitutionInstitutions in order to obtain a “legal proxy,” which will allow them to both attend the meeting and vote in person.electronically during the meeting. Without a legal proxy, Beneficial Holders cannot vote atelectronically during the Annual Meeting because their Financial Institution may have already voted or returned a Broker Non-Vote on their behalf.Meeting.
Holders of proxies solicited by this Proxy Statement will vote the proxies received by them as directed on the proxy card or, if no direction is made, then FOR each of the nomineesnominee listed in Proposal No. 1 and FOR each of the other proposals described below.Proposals No. 2 and No. 3.
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PROPOSAL NO. 1

ELECTION OF CLASS I DIRECTORSDIRECTOR
Overview
The Company’s Amended and Restated Articles of Incorporation, as amended (the “Articles of Incorporation”), provide that the Board is to be divided into three classes as nearly equal in number as possible, with directors in each class serving staggered three-year terms. The total Board size is currently fixed at sevenfive directors. The Class I director (whose term expires at the Annual Meeting) is Daniel J. O’Connor, J.D. The Class II directors (whose terms expire at the Annual Meeting)2024 annual meeting of stockholders) are Kleanthis G. Xanthopoulos,Raj Mehra, Ph.D., and Paul V. Maier.Brian Lian, Ph.D. The Class III directors (whose terms expire at the 2017 annual meeting of stockholders) are Rusty Ray and Wendell Wierenga, Ph.D. The Class II directors (whose terms expire at the 20182023 annual meeting of stockholders) are Richard W. Pascoe and Sandford D. Smith.Margaret Dalesandro, Ph.D. The Class I directorsdirector elected at the Annual Meeting will hold office until the 20192025 annual meeting of stockholders, and until their successors arehis successor is elected and qualified, unless they resignhe resigns or their seats becomehis seat becomes vacant due to death, removal or other causeotherwise in accordance with the Company’s Bylaws.Amended and Restated Bylaws (the “Bylaws”).
As described below, the Board has nominated Kleanthis G. Xanthopoulos, Ph.D. and Paul V. MaierDaniel J. O’Connor, J.D. for re-election as a Class I directors. Eachdirector. The nominee for election as a director at the Annual Meeting has indicated theirhis willingness to serve if elected. Should anythe nominee become unavailable for election at the Annual Meeting, either of the persons named on the enclosed proxy as a proxy holdersholder may vote all proxies given in response to this solicitation for the election of a substitute nominee chosen by our Board.
Nomination of Directors
The Corporate Governance/Nominating Committee of the Board (the “Corporate Governance/Nominating Committee”), which acts as the nominating committee of the Board, reviews and recommends potential candidates for election to the Board. In reviewing potential candidates, the Corporate Governance/Nominating Committee considers the qualifications described below under the captionsection titled “Board of Directors and Committees and Corporate Governance - Director Nominations and Stockholder Communications.” After reviewing the qualifications of potential Board candidates, the Corporate Governance/Nominating Committee presents its recommendations to the Board, which selects the final director nominees.nominee(s). The Corporate Governance/Nominating Committee recommended each of the nomineesnominee for director identified in this Proxy Statement. We did not pay any fees to any third parties to identify or assist in identifying or evaluating nominees for consideration for election at the Annual Meeting.
Information Regarding Nominees and Incumbent Directors
The Corporate Governance/Nominating Committee has recommended, and the Board has nominated, Kleanthis G. Xanthopoulos, Ph.D. and Paul V. MaierDaniel J. O’Connor, J.D. to be re-elected as Class I directorsdirector at the Annual Meeting. The following table contains information about the nomineesnominee and about each of the Company’s continuing directors: the year eachhe or she was firstinitially elected as a director, their respective ageshis or her age as of April 12, 2022, the Record Date, the positions currently heldposition(s) with the Company currently held by him or her, the year theirhis or her current term as a director will expire and theirhis or her current director class:
Name
Year
Initially
Elected
Age
Position(s)
Expiration of
Term
Class
Daniel J. O’Connor, J.D.
2019
57
Director
2022
I
Raj Mehra, Ph.D.
2019
62
Chairman, Chief Executive Officer and President
2024
II
Brian Lian, Ph.D.(1)(2)(3)
2019
56
Director
2024
II
Richard W. Pascoe(1)(3)
2013
58
Director
2023
III
Margaret Dalesandro, Ph.D.(1)(2)
2021
75
Director
2023
III
Name 
Year Initially
Elected
 Age Position(s) 
Expiration of
Term
 Class
Kleanthis G. Xanthopoulos, Ph.D. 2011 57 Chairman 2016 I
Paul V. Maier 2012 68 Director 2016 I
Rusty Ray 2009 45 Director 2017 III
Wendell Wierenga, Ph.D. 2014 68 Director 2017 III
Richard W. Pascoe 2013 52 Chief Executive Officer, Secretary & Director 2018 II
Sandford D. Smith 2014 69 Director 2018 II
(1)
Member of the Audit Committee of the Board (the “Audit Committee”).
(2)
Member of the Corporate Governance/Nominating Committee.
(3)
Member of the Compensation Committee of the Board (the “Compensation Committee”).
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Class I DirectorsDirector Nominated for Election
The following persons haveindividual has been nominated by our Board to be elected as a Class I directorsdirector at the Annual Meeting:
Kleanthis G. Xanthopoulos, Ph.D.Daniel J. O’Connor, J.D. has been a director since November 2011 and became Chairman ofJanuary 2019. Mr. O’Connor has served as the Board in December 2013. Dr. Xanthopoulos is an experienced and visionary leader in the biotechnology and pharmaceutical research industries, with a strong foundation in both operations and corporate development. He has been a Partner at the Vandel-Group, a life sciences investment company, since August 2015. From 2007 to June 2015, he was the President and Chief Executive Officer and a memberChairman of the board of directors of Regulus Therapeutics Inc. (RGLS). Prior to joining Regulus in 2007, Dr. Xanthopoulos was the Managing Director of Enterprise Partners Venture Capital.Larkspur Health Acquisition Corp. (Nasdaq: LSPR), a special purpose acquisition company, since March 2021. He co-founded Anadys Pharmaceuticals, Inc., served as their President


andthe Chief Executive Officer from 2000 to 2006, and remained a director of OncoSec Medical Incorporated from 2017 to 2021. Prior to that, Mr. O’Connor served as President, Chief Executive Officer, Director and in other senior roles at Advaxis, Inc., a cancer immunotherapy company, from January 2013 until its acquisition by Rochehis resignation in 2011. BeforeJuly 2017. Prior to that, Dr. XanthopoulosMr. O’Connor was Senior Vice President and General Counsel for BRACCO Diagnostics Inc., a diagnostic imaging company, from 2008 until 2012; Senior Vice President, General Counsel and Secretary for ImClone Systems Incorporated, a biopharmaceutical company, from 2002 until 2008; and General Counsel at Aurora Biosciences (acquired by Vertex Pharmaceuticals)PharmaNet (formerly inVentiv Health, now Syneos Health), a clinical research company, from 1997 to 2000, and Section Head1998 until 2001. Mr. O’Connor is a 1995 graduate of the National Human Genome Research InstitutePennsylvania State University’s Dickinson School of Law in Carlisle, Pennsylvania and previously served as a Trusted Advisor to its Dean. He graduated from 1995 to 1997. Previously, hethe United States Marines Corps Officer Candidate School in 1988 and was commissioned as an Associate Professor atofficer in the Karolinska Institute, Stockholm, Sweden. Dr. Xanthopoulos isU.S. Marines, attaining the rank of Captain while serving in Saudi Arabia during Operation Desert Shield. Mr. O’Connor was also a member of the boardBoard of directorsTrustees of BioNJ from 2015 to 2021 and previously served as its Vice Chairman and Chairman of its Nominating Committee for several years. In October 2017, Mr. O’Connor was appointed to the New Jersey Biotechnology Industry Organization (BIO) and Zosano Pharma Inc. (ZSAN) and heTask Force by its Governor. Prior to his career in drug development, Mr. O’Connor was a former criminal prosecutor in Somerset County, New Jersey. The Board believes Mr. O’Connor is a co-founder and a member of the board of directors of Sente, Inc. Additionally, Dr. Xanthopoulos received the Ernst & Young Entrepreneur of the Year Award in Health Sciences in 2006 and was named Most Admired CEO by the San Diego Business Journal in 2013. An Onassis Foundation Scholar, Dr. Xanthopoulos received his B.Sc. in Biology with honors from Aristotle University of Thessaloniki, Greece, and his M.Sc. degree in Microbiology and Ph.D. degree in Molecular Biology from the University of Stockholm, Sweden, and a Postdoctoral Research Fellowship at The Rockefeller University, New York. Dr. Xanthopoulos’ qualificationsqualified to serve as a director based on the Board includedepth and diversity of his scientific background and ability to contribute to the Board’s understandingexperience in senior management of technical matters relating to the Company’s business, as well as Dr. Xanthopoulos’ broader business development and corporate experience.
Paul V. Maier has been a director since June 2012. He is the Chair of our Audit Committee and a member of our Corporate Governance/Nominating Committee. Mr. Maier was most recently the Chief Financial Officer of Sequenom, Inc. from November 2009 until June 2014. Prior to joining Sequenom, Mr. Maier served as Senior Vice President and Chief Financial Officer of Ligand Pharmaceuticals Incorporated from 1992 until 2007, where he helped build Ligand from a venture stage company to a commercial, integrated biopharmaceutical organization. Prior to joining Ligand, he spent six years in various management and finance positions at ICN Pharmaceuticals, Inc. Mr. Maier currently serves on a number of boards, including public companies like International Stem Cell Corporation, where he is Chair of the company’s audit and a member of the compensation committees, MabVax Therapeutics Holdings Inc., where he is Chair of the company’s audit and a member of the governance committee, and Ritter Pharmaceuticals, Inc., where he is Chair of the audit committee and a member of the compensation committee. Mr. Maier also serves on the board of Biological Dynamics, a private company. Mr. Maier previously served on the board of directors of the following public companies: Pure Bioscience and Talon Therapeutics, Inc. (previously Hana Bioscience). Mr. Maier was also an independent financial consultant from 2007 through 2009. He received his M.B.A. from Harvard Business School and a B.S. from Pennsylvania State University. Mr. Maier’s qualifications to serve on the Board include his management and finance background and his ability to contribute to the Board’s understanding of technical matters relating to the Company’s business, as well as Mr. Maier’s broader business and corporate experience.pharmaceutical companies.
Class IIIII Directors Continuing in Office until 20172024
The following directors will continue in office until the 20172024 annual meeting of stockholders, or until their earlier resignation or removal in accordance with our Bylaws:
Rusty RayRaj Mehra, Ph.D., has been our President, Chief Executive Officer and Chairman of the Board of Directors since January 2019. He also served as our Interim Chief Financial Officer from January 2019 until September 2021. Dr. Mehra has served as a director at Larkspur Health Acquisition Corporation (Nasdaq: LSPR), a special purpose acquisition company, since December 2009.July 2021. Prior to founding Seelos, Dr. Mehra spent nine years at Auriga USA, LLC as a Managing Director focused on private and public equity investments in global healthcare companies. Prior to Auriga, Dr. Mehra was the sector head for healthcare equity investments at Bennett Lawrence Management, LLC in New York. He also founded and managed a long-short equity hedge fund at Weiss, Peck & Greer LLC. Dr. Mehra started his career as an investment professional at Cowen Asset Management, LLC. Dr. Mehra holds M.S., M.Phil., Ph.D., JD and MBA degrees from Columbia University in New York. He is the Chairalso a graduate of our Corporate Governance/Nominating Committee and a memberIndian Institute of our Audit Committee.  He is currently a partner with 11T Partners, a healthcare-only investment bank. He has worked with a wide variety of clients across the healthcare industry ranging from large pharmaceutical companies to early-stage drug development companies to medical device and service-based companies. Mr. Ray was a partner with Brocair Partners, a healthcare investment banking boutique, beginning in 2004 until he formed 11T Partners in 2012. Mr. Ray served as Deputy Director for eight years with Resources for the Future (“RFF”) a non-partisan Washington-based think-tank that conducts independent economic research. During his tenure, RFF conducted a number of studies related to the pharmaceutical and biotechnology industries. Prior to joining RFF, Mr. Ray worked with The Meningitis Research Foundation in LondonTechnology, Kanpur, where he worked to support basic research to cure the disease. Beyond life sciences, Mr. Ray has also worked on issues related to emissions credit trading and utility restructuring. He has served on the board of directors of New Media Mill LLC since 2002. Mr. Ray holds an M.B.A.was ranked first in Finance from the Fordham University School of Business and a B.S. in Biology from Wake Forest University. Mr. Ray resides in New York with his wife and daughter. Mr. Ray’s qualificationsclass. The Board believes Dr. Mehra is qualified to serve as our Chairman based on the Board include his experience in the healthcare industry, as well asincluding his significant business knowledge based on his experience with healthcare-based investment banking.
Brian Lian, Ph.D.Wendell Wierenga, Ph.D., has been a director since March 2014.January 2019. He is the Chair of our Compensation Committee and our Audit Committee and a member of our CompensationCorporate Governance/Nominating Committee. He is currently President and Chief Executive Officer and a Director of Viking Therapeutics, Inc. (Nasdaq: VKTX), a biopharmaceutical company. Dr. Wierenga brings to our BoardLian has over four decades15 years of experience in the biotechnology and financial services industries. Prior to joining Viking, he was a Managing Director and Senior Research Analyst at SunTrust Robinson Humphrey, an investment bank, from 2012 to 2013. At SunTrust Robinson Humphrey, he was responsible for coverage of small and mid-cap biotechnology companies with an emphasis on companies in the diabetes, oncology, infectious disease and neurology spaces. Prior to SunTrust Robinson Humphrey, he was Managing Director and Senior Research Analyst at Global Hunter Securities, an investment bank, from 2011 to 2012. Prior to Global Hunter Securities, he was Senior Healthcare Analyst at The Agave Group, LLC, a registered investment advisor, from 2008 to 2011. Prior to The Agave Group, he was an Executive Director and Senior Biotechnology Analyst at CIBC World Markets, an investment bank, from 2006 to 2008. Prior to CIBC, he was a research scientist in small molecule drug discovery at Amgen, a biotechnology company. Prior to Amgen, he was a research scientist at Microcide Pharmaceuticals, a biotechnology company. Dr. Lian holds an MBA in accounting and drug development, including clinical research, regulatory affairs, manufacturing, safety,finance from Indiana University, an MS and medical affairs. He has an extensive background servingPh.D. in organic chemistry from The
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University of Michigan, and a BA in chemistry from Whitman College. The Board believes Dr. Lian is qualified to serve as a public company executive and board memberdirector based on his experience in the pharmaceutical and biotechnology industries. He most recently served as Executive Vice President, Research and Development, at Santarus, Inc., a specialty biopharmaceutical company, from June 2011 until its acquisition by Salix Pharmaceuticals, Inc. in 2014. Prior to Santarus, he was Executive Vice President in Research and Development at Ambit Biosciences Corporation from 2007 until 2011 and Neurocrine Biosciences, Inc. from 2003 until joining Ambit. Additionally, Dr. Wierenga served as Chief Executive Officer of Syrrx, Inc. (now part of Takeda Pharmaceutical Company), Senior Vice President of Worldwide Pharmaceutical Sciences, Technologies and Development at Parke-Davis/Warner Lambert (now Pfizer, Inc.), and he spent 16 years at Upjohn Pharmaceuticals in research and drug discovery roles. Dr. Wierenga’s most recent board appointments to public companies include Anacor Pharmaceuticals Inc. and Concert Pharmaceuticals, Inc. He has served as a member of the board of directors of the following private companies, Patara Pharma LLC and Crinetics Pharmaceuticals Inc.,


since June and November of 2015, respectively. He also serveshealthcare industry, including his significant business knowledge based on the board and as a member of the compensation committee at the following public companies, Ocera Therapeutics Inc., Cytokinetics Inc. and XenoPort, Inc. and he was previously on the board of directors of Onyx Pharmaceuticals, Inc. (acquired by Amgen). Additionally, Dr. Wierenga serves on multiple scientific advisory boards, including Concert Pharmaceuticals, Ferring Pharmaceuticals, and aTyr Pharma, Inc. He holds a Ph.D. in Chemistry from Stanford University and a B.A. in Chemistry from Hope College. Dr. Wierenga’s qualifications to serve on the Board include his scientific background and ability to contribute to the Board’s understanding of technical matters relating to the Company’s business, as well as Dr. Wierenga’s broader business development and corporate experience.experience with healthcare-based investment banking.
Class IIIII Directors Continuing in OfficerOffice until 20182023
The following directors will continue in office until the 20182023 annual meeting of stockholders, or until their earlier resignation or removal in accordance with our Bylaws:
Richard W. Pascoe has been a director since March 2013. He is a member of our Audit Committee and our Compensation Committee. Mr. Pascoe is currently the Executive Chairman of KemPharm, Inc., a specialty pharmaceutical company. He served as the Chairman and Chief Executive Officer of Histogen Inc., a private regenerative medicine company, from January 2019 until November 2021. He previously served as our Chief Executive Officer sincefrom March 2013 to January 2019, our Secretary from February 2015 to January 2019, and has served as the Company’s Secretary since February 2015.our Principal Financial Officer and Principal Accounting Officer from December 2016 to January 2019. He joined the Company following the merger of Somaxon Pharmaceuticals, Inc. with Pernix Therapeutics Holdings, Inc. Mr. Pascoe was the Chief Executive Officer of Somaxon from August 2008 until joining the Company and was responsible for the FDA approval of Somaxon’s lead drug Silenor®Silenor®. Prior to Somaxon, Mr. Pascoe was with ARIAD Pharmaceuticals, Inc., a specialty pharmaceutical company where he was most recently Senior Vice President and Chief Operating Officer. Prior to joining ARIAD in 2005, Mr. Pascoe held a series of senior management roles at King Pharmaceuticals, Inc. (acquired by Pfizer Inc.), including Senior Vice President positions in both marketing and sales, as well as Vice President positions in both international sales and marketing and hospital sales. Prior to King, Mr. Pascoe was in the commercial groups at Medco Research, Inc. (acquired by King), COR Therapeutics, Inc. (acquired by Millennium Pharmaceuticals Inc., the Takeda Oncology Company), B. Braun Interventional and The BOC Group. Mr. Pascoe is a member of the board of directors of KemPharm, Inc., as well as a member of the company’s audit and compensation committees and its lead independent director. He also serves as a member of the board of directors of Biocom and the Johnny Mac Soldiers Fund, a charity for military veterans. Mr. Pascoe is a past member and chairman of the board of directors of BIOCOM. Mr. Pascoe served as a Commissioned Officer with the U.S. Army 24th Infantry Division.Division and continues to serve as a Civilian Aid to the Secretary of the Army. He is a graduate of the United States Military Academy at West Point where he received a B.S. degree in Leadership. The Board believes Mr. Pascoe was appointed to the Board in connection with his appointment as our Chief Executive Officer. Mr. Pascoe’s qualificationsis qualified to serve as a director based on the Board include the depth and diversity of his experience in senior management of public pharmaceutical companies and his personal and professional integrity, ethics and values.companies.
Margaret Dalesandro, Ph.D.Sandford D. Smith, has beenserved as a directormember of the Board since August 2014. HeSeptember 2021. She is the Chair of our Corporate Governance/Nominating Committee and a member of our CompensationAudit Committee. Mr. SmithShe has been actively engaged in the development of international biotech and pharmaceutical companies for almost four decades.  Most recently, Mr. Smith served as Interim Chief Executive Officer at Aegerion Pharmaceuticals, Inc. from July 2015 to January 2016, and now serves as Aegerion Chairman. He is chair/founder of Global BioLinka pharmaceutical development consultant with Brecon Pharma Consulting LLC a biotech consultancy formed in 2011. He was President of Genzyme International and Executive Vice President of Genzyme Corporation until the company’s acquisition by Sanofi in 2011. He joined Genzyme in 1996, and initiallysince December 2012. Since August 2020, Dr. Dalesandro has served as Vice President and General Manager of Genzyme International and President of Genzyme Specialty Therapeutics. Prior to joining Genzyme, Mr. Smith was President and Chief Executive Officer at RepliGen Corporation, a publicly traded biotechnology company, from 1986-1995. Mr. Smith previously held leadership positions at Bristol-Myers Squibb from 1977-1985, including Director of Operations for Bristol-Myers Squibb–Asia Pacific and Vice President of Business Development and Strategic Planning for the Pharmaceutical and Nutritional Division. Mr. Smith currently servesan independent director on the board of directors of publicly traded biotechnology companies Cytokinetics, Incorporated, Aegerion Pharmaceuticals,Skye Bioscience, Inc. and Neuralstem,(previously Emerald Bioscience, Inc. He is). Dr. Dalesandro served on the advisory council for non-profit Brigham & Women’s Hospital, where he createdboard of directors of OncoSec Medical Incorporated from March 2019 (and as the Smith Scholars ResidencyChair of the board of directors since April 2020) until December 2021. She previously served as a Business Director of Integrative Pharmacology at Corning, Incorporated, as a Vice President of Project, Portfolio and Alliance Management at ImClone Systems Inc., as an Executive Director of Project and Portfolio Management at GlaxoSmithKline, and as a Senior Consultant at Cambridge Pharma Consultancy over the course of her career. Dr. Dalesandro earned her Ph.D. in medical educationBiochemistry from Bryn Mawr College and completed a NIH Post-Doctoral Fellowship in Molecular Immunology at the Wake Forest University School of Medicine. The Board believes Dr. Dalesandro is qualified to benefit physicians from resource-poor nations. He is alsoserve as a director based on the advisory board at Tullis Health Advisors. Mr. Smith holds a bachelor’s degree from the Universitydepth and diversity of Denver. Mr. Smith’s qualifications to serve on the Board include his wealth ofher experience in senior management of pharmaceutical companies and board level experience from his leadership roles in both the biotech and pharmaceutical industries.healthcare industry.
Class II Director Resigned from the BoardFamily Relationships
On April 5, 2016, the Board reduced the sizeThere are no family relationships among any of the Board from seven to six directors. As a result, effectiveindividuals who serve as of April 5, 2016, Deirdre Y. Gillespie, M.D. resignedour directors or executive officers.
Executive Officer and Director Interest
Mr. O’Connor has an interest in this Proposal No. 1, as he is currently a member of theour Board. Dr. Gillespie’s resignation was not related to a disagreement with the Company concerning any matter relating to its operations, policies or practices.
Vote Required and Majority Vote Standard
MembersAssuming that a quorum is present at the Annual Meeting, nominees to serve as members of the Board are elected by a plurality vote.of the votes cast. However, pursuant to the Company’s corporate governance guidelines, if
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the number of nominees for election to the Board is equal to, or less than, the number of seats open for election and a nominee receives a greater number of votes “withheld” than votes “for” such nominee’s election, then such nominee must submit an offer of resignation to the Board. The Corporate Governance/Nominating Committee will then consider the offer of resignation and other relevant circumstances and recommend a course of action to the Board. The disinterested members of the Board will then determine whether to accept the offer of resignation.


Any shares that are not voted for any reason, including abstentions and Broker Non-Votes, will not be counted as votes cast and will not affect the outcome of the election of directors.
Holders of proxies solicited by this Proxy Statement will vote the proxies received by them as directed on the proxy card or, if no direction is made, then FOR the election of the nomineesnominee named above.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR EACH OF THE NOMINEES
NOMINEE IDENTIFIED ABOVE.
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PROPOSAL NO. 2
RATIFICATION OF APPOINTMENT OF INDEPENDENT
REGISTERED PUBLIC ACCOUNTING FIRM
The Audit Committee of the Board has selected BDO USA,KPMG LLP (“BDOKPMG”) as our independent registered public accounting firm to audit our consolidated financial statements for the fiscal year ending December 31, 2016,2022, and has further directed that we submit the selection of BDOKPMG for ratification by our stockholders at the Annual Meeting. KPMG audited our financial statements for the year ended December 31, 2021. Although ratification is not required by our Bylaws or otherwise, the Board is submitting this proposal as a matter of good corporate practice. If the stockholders fail to ratify the selection, the Audit Committee will reconsider whether or not to retain KPMG. Even if the selection is ratified, the Audit Committee in its discretion may decide to appoint a different independent registered public accounting firm at any time during the year if the Audit Committee determines that such a change would be in the best interests of the Company and its stockholders. A representative of BDOKPMG will be present atduring the Annual Meeting to make a statement and respond to appropriate questions. The Company does not expect a representative of Pricewaterhouse Coopers LLP (“PwC”), the Company’s former independent registered public accounting firm, to be present at the Annual Meeting.
Fees for Independent Registered Public Accounting Firm
On March 18, 2015, the Company, at the discretion of the Audit Committee of the Board, dismissed PwC as the Company’s independent registered public accounting firm. The Company then engaged BDO to serve as the Company’s independent registered public accounting firm. The Company filed a Current Report on Form 8-K on March 23, 2015 reporting this change. PwC was not engaged to audit the Company’s financial statements for the fiscal year ended December 31, 2015.
The reports of PwC on the consolidated financial statements of the Company for the fiscal years ended December 31, 2014 and 2013 contained no adverse opinion or disclaimer of opinion and were not qualified or modified as to uncertainty, audit scope or accounting principles.
During the Company’s fiscal years ended December 31, 2014 and 2013 and the subsequent interim period through March 18, 2015, there were no disagreements with PwC on any matter of accounting principles or practices, financial statement disclosure or auditing scope or procedure, which disagreements, if not resolved to the satisfaction of PwC, would have caused them to make reference thereto in their reports on the consolidated financial statements for such fiscal years.
During the Company’s fiscal years ended December 31, 2014 and 2013 and the subsequent interim period through March 18, 2015, there have been no reportable events (as defined in Item 304(a)(1)(v) of Regulation S-K), except as previously reported in the Company’s Annual Reports on Form 10-K for the fiscal years ended December 31, 2014 (the “2014 Form 10-K”) and December 31, 2013 (the “2013 Form 10-K”). Specifically, as of each of December 31, 2014 and 2013, material weaknesses existed in the Company’s internal control over financial reporting over the accounting for and disclosures of technical accounting matters in the consolidated financial statements and effective monitoring and oversight over the controls in the financial reporting process. The control deficiencies related to the Company’s failure to maintain a sufficient complement of resources with an appropriate level of accounting knowledge, experience and training commensurate with the Company’s structure and financial reporting requirements. Also, the control deficiencies resulted in having controls that were not effectively designed or maintained to sufficiently mitigate the risks of material misstatements including controls over the statement of cash flows, discontinued operations, journal entries, consolidation and classification of accounts in the consolidated financial statements. The deficiencies resulted in audit adjustments: for the interim period ended March 31, 2014 related to the cash flows presentation of certain noncash disclosures; for the year ended December 31, 2013 related to general and administrative, and cost of services revenue of the Company’s former subsidiaries Scomedica SAS, NexMed Europe SAS and NexMed Pharma SAS (the “French Subsidiaries”), deferred cost and research and development expense, accrued expenses as well as audit adjustments identified related to prepaid expenses and trade accounts payable, the presentation of earnings per share, presentation related to the sale of the BQ Kits, Inc. business, the cash flows presentation associated with the deconsolidation of the Company’s former French Subsidiaries, and certain income tax disclosures; for the year ended December 31, 2012 related to the identification of and accounting for an embedded derivative associated with the convertible note, presentation and disclosure related to the sale of the Bio-Quant business and associated cash flows and certain income tax disclosures. These material weaknesses and the Company’s remediation efforts are further described in Item 9A to the 2014 Form 10-K and the 2013 Form 10-K.
The previously identified material weaknesses have been remediated as of December 31, 2015 and the Company believes its remediation efforts have enhanced the overall effectiveness of its internal control over financial reporting, as well as its disclosure controls and procedures.
During the fiscal years December 31, 2014 and December 31, 2013 and the subsequent interim period prior to engaging BDO, neither the Company nor anyone on its behalf has consulted with BDO regarding (i) the application of accounting principles to a specific transaction, either completed or proposed or (ii) the type of audit opinion that might be rendered on the Company's consolidated financial statements and, in the case of either (i) or (ii), a written report or oral advice that BDO concluded was an important factor considered by the Company in reaching a decision as to accounting, auditing or financial reporting issues, or (iii) any matter that was the subject of a disagreement within the meaning of Item 304(a)(1)(iv) of Regulation S-K, or (iv) any “reportable event” within the meaning of Item 304(a)(1)(v) of Regulation S-K.


The following is a summary of the fees billed to the Company by BDO and PwCKPMG for professional services rendered for the fiscal years ended December 31, 20152021 and 2014,2020, respectively:
 
2021
2020
Audit Fees(1)
$453,500
$509,000
Audit Related Fees
Tax Fees(2)
20,700
15,500
All Other Fees
Total All Fees
$474,200
$524,500
  BDO PwC
  2015 2014
Audit Fees (1):
 $340,000
 $755,000
Other Fees:    
Audit-Related Fees (2)
 $
 $
Tax Fees    
Tax compliance (3)
 $20,000
 $53,000
Tax consulting (4)
 $
 $29,000
All Other Fees (5)
 
 
Total Other Fees $20,000
 $82,000
Total All Fees $360,000
 $837,000
(1)Consists of fees billed for professional services rendered for the audit of the Company’s annual financial statements and the review of the interim financial statements included in the Company’s Quarterly Reports (together, the “Financial Statements”) and for services normally provided in connection with regulatory filings or engagements
(2) Consists of fees billed for assurance and related services reasonably related to the performance of the annual audit or review of the Financial Statements (defined above)
(3) Consists of fees billed for tax compliance
(4) Consists of fees billed for tax consulting
(5) Consists of fees billed for other products and services not described above
(1)
Audit fees consist of estimated fees for professional services rendered for the audit of our annual financial statements included in our Form 10-K filing and review of financial statements included in our quarterly Form 10-Q filings, reviews of registration statements and issuances of consents, comfort letters and services that are normally provided in connection with statutory and regulatory filings or engagements.
(2)
Consists of fees billed for tax compliance and consulting.
Pre-Approval Policies and Procedures
All audit and non-audit services provided by BDOKPMG must be pre-approved by the Audit Committee. BDOKPMG will provide the Audit Committee with an engagement letter during the first half of the fiscal year, outlining the scope of the proposed services and estimated fees for the fiscal year. Pre-approval may be given for a category of services, provided that (i) the category is reasonably narrow and detailed and (ii) the Audit Committee establishes a fee limit for such category. The Audit Committee may delegate to any other member of the Audit Committee the authority to grant pre-approval of permitted non-audit services to be provided by BDOKPMG between Audit Committee meetings; provided, however, that any such pre-approval shall be presented to the full Audit Committee at its next scheduled meeting. The Audit Committee pre-approved all audit and permitted non-audit services provided by PwCKPMG in fiscal 20142021 and such services provided by BDO2020.
Executive Officer and Director Interest
Our directors and executive officers do not have an interest in fiscal 2015.this Proposal No. 2.
Required Vote
Assuming that a quorum is present at the Annual Meeting, approval of this proposal requires the affirmative vote of the majority of the votes cast (meaning the number of shareshares voted “for” the proposal must exceed the number of shares voted “against” the proposal). Abstentions from voting on the proposal will not be counted as votes cast and accordingly will have no effect upon the outcome of the proposal. The approval of Proposal No. 2 is a routine proposal on which a broker or other nominee has discretionary authority to vote. If our stockholders do not ratify the selection of KPMG, our Board will consider the selection of KPMG as well as other independent auditors.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR RATIFICATION OF THE APPOINTMENT OF KPMG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 2022.
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PROPOSAL NO. 3
ADVISORY VOTE ON EXECUTIVE COMPENSATION
Our executive compensation program embodies a pay-for-performance philosophy that supports our business strategy and aligns the interests of our executives with our stockholders. In particular, our compensation program rewards financial, strategic and operational performance and the goals set for each performance category support our short and long-term plans.
We are requesting that our stockholders vote to approve the compensation of our Named Executive Officers (as defined below) as described below under the section titled “Executive Compensation” pursuant to the compensation disclosure rules of the Securities and Exchange Commission (the “SEC”), which disclosures include the compensation tables and the narrative discussion following the compensation tables.
This advisory vote is generally referred to as a “say-on-pay vote” and is being provided pursuant to Section 14A of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). In accordance with the results of the advisory vote held at our 2019 annual meeting of stockholders on the frequency of future say-on-pay votes, we are conducting say-on-pay votes every year.
The Board is asking stockholders to cast an advisory (non-binding) vote FOR the following resolution:
“RESOLVED, that the compensation paid to the Company’s Named Executive Officers, as disclosed pursuant to Item 402 of Regulation S-K, including the compensation tables and narrative discussion within the section of the Company’s proxy statement entitled “Executive Compensation,” is hereby APPROVED.”
Although the vote we are asking you to cast is non-binding, the Compensation Committee and the Board value the views of our stockholders and will consider the outcome of the vote when determining future compensation arrangements for our Named Executive Officers and other executive officers.
Executive Officer and Director Interest
Our executive officers have an interest in this Proposal No. 3, as the compensation for our executive officers is subject to this vote.
Required Vote
Assuming that a quorum is present at the Annual Meeting, approval of this proposal requires the affirmative vote of the majority of the votes cast (meaning the number of shares voted “for” the proposal must exceed the number of shares voted “against” the proposal). Abstentions from voting on the proposal and Broker Non-Votes will not be counted as votes cast and accordingly will have no effect upon the outcome of the proposal. If our stockholders do not ratify the selection of BDO, our Board will consider the selection of BDO as well as other independent auditors.
THE BOARD OF DIRECTORS RECOMMENDS A VOTE FORRATIFICATION OF THE APPOINTMENT OF BDO USA, LLPAS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR THE YEAR ENDING DECEMBER 31, 2016.



PROPOSAL NO. 3
ADVISORY VOTE ON EXECUTIVE COMPENSATION
The Compensation Discussion and Analysis beginning on page 13 of this Proxy Statement describes the Company’s executive compensation program and the compensation decisions that the Compensation Committee and the Board made with respect to the compensation of our Named Executive Officers in 2015. The Board is asking stockholders to cast an advisory (non-binding) vote FOR the following resolution:
“RESOLVED, that the compensation paid to the Company’s Named Executive Officers, as disclosed pursuant to Item 402 of Regulation S-K, including the Compensation Discussion and Analysis, compensation tables and narrative discussion, is hereby APPROVED.”
As we describe in the Compensation Discussion and Analysis, our executive compensation program embodies a pay-for-performance philosophy that supports the Company’s business strategy and aligns the interests of our executives with our stockholders. In particular, our compensation program rewards financial, strategic and operational performance and the goals set for each performance category support our short and long-term plans.
For these reasons, the Board is asking stockholders to support this proposal. Although the vote we are asking you to cast is non-binding, the Compensation Committee and the Board value the views of our stockholders and will consider the outcome of the vote when determining future compensation arrangements for our Named Executive Officers.
Required Vote
Assuming that a quorum is present at the Annual Meeting, approval of this proposal requires the affirmative vote of the majority of the votes cast (meaning the number of shares voted “for” the proposal must exceed the number of share voted “against” the proposal). Abstentions from voting on the proposal and Broker Non-Votes will not be counted as votes cast and accordingly will have no effect upon the outcome of the proposal.
THE BOARD OF DIRECTORS RECOMMENDS A VOTEFORAPPROVAL, ON AN ADVISORY BASIS, OF THE COMPENSATION PAID TO THE COMPANY’S NAMED EXECUTIVE OFFICERS, AS DISCLOSED PURSUANT TO ITEM 402 OF REGULATION S-K, INCLUDING THE COMPENSATION DISCUSSION AND ANALYSIS, COMPENSATION TABLES AND NARRATIVE DISCUSSION.DISCUSSION WITHIN THE SECTION OF THIS PROXY STATEMENT ENTITLED “EXECUTIVE COMPENSATION”.
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BOARD OF DIRECTORS AND COMMITTEES AND CORPORATE GOVERNANCE
Meetings of the Board
During fiscal 2015,2021, the Board met thirteenfour times and acted by unanimous written consent five times. EachExcept for Dr. Dalesandro, each director attended at least 90%75% of the aggregate of (i) the total number of meetings of the Board and (ii) the total number of the meetings of the committees of the Board on which theyhe or she served during the periods that theyhe or she served. Dr. Dalesandro was unable to attend one meeting of the Audit Committee in 2021 due to scheduling conflicts with the one meeting of the Audit Committee that was held in 2021 following her appointment to the Board in September 2021, which meeting had been pre-scheduled prior to her appointment to the Board and the Audit Committee. Although we expectencourage directors to attend each annual meeting of stockholders and expect any of them in attendance to be available to answer appropriate questions from our stockholders, we have no formal policy requiring attendance by directors at annual stockholder meetings. All of the members of the Board serving at the time of our 20152021 annual meeting of stockholders except for Kleanthis G. Xanthopoulos, Ph.D., attended the 20152021 annual meeting of stockholders, in person or by telephone.stockholders.
Committees of the Board
There are currently three active committees of the Board: the Audit Committee, the Corporate Governance/Nominating Committee and the Compensation Committee. Below are descriptions of our three active Board committees.
The Audit Committee regularly meets with our financial and accounting management and independent auditors and is responsible for the selection and engagement of the Company’sour independent auditors. Additionally, the Audit Committee reviews with the independent auditors the scope and results of the audit engagement, approves professional services provided by the independent auditors, reviews the independence of the independent auditors and reviews the adequacy of the internal accounting controls. The Audit Committee acts under a written charter, a copy of which is available on the Company’sour website at www.apricusbio.com. Thewww.seelostherapeutics.com/corporate-governance/. During fiscal 2021, the Audit Committee met sixfour times in fiscal 2015, and asdid not take any action by unanimous written consent. As of April 12, 2022, the Record Date,Audit Committee consisted of Paul V. MaierBrian Lian, Ph.D. (Chair), Deirdre Y. Gillespie, M.D.Margaret Dalesandro, Ph.D., and Rusty Ray,Richard W. Pascoe, none of whom was an employee of the Companyours and each of whom met the applicable independence standards promulgated by the NASDAQ Marketplacerules of The Nasdaq Stock Market LLC (the “Nasdaq Rules”) and thoseapplicable rules of the Securities and Exchange Commission (the “SEC”).SEC. The Board has also determined that each of Dr. Lian and Mr. MaierPascoe qualifies as an “audit committee financial expert,” as defined in Item 407(d)(5) of the SEC’s Regulation S-K.
The Corporate Governance/Nominating Committee makes recommendations to the Board regarding the election of directors, as well as providing guidance and oversight on matters relating to corporate governance. TheDuring fiscal 2021, the Corporate Governance/Nominating Committee met two times in fiscal 2015,did not meet and asacted by unanimous written consent once. As of April 12, 2022, the Record Date,Governance/Nominating Committee consisted of Rusty RayMargaret Dalesandro, Ph.D. (Chair) and Brian Lian, Ph.D., Deirdre Y. Gillespie, M.D. and Paul V. Maier, noneneither of whom was an employee of the Companyours and each of whom met the independence requirements of the NASDAQ Marketplace.Nasdaq Rules. The Corporate Governance/Nominating Committee acts under a written charter, which is available on our website at www.apricusbio.comwww.seelostherapeutics.com/corporate-governance/. We have not paid any third party a fee to assist in the process of identifying and evaluating candidates for director, and as of the Record Date we have not received any nominees for director from any stockholder or stockholder group for the Annual Meeting in accordance with the nominating procedures set forth in our Bylaws and the charter for our Corporate Governance/Nominating Committee.
The Compensation Committee determines compensation levels for our executive officers, implements incentive programs for officers, directors and consultants, and administers our equity compensation plans. TheDuring fiscal 2021, the Compensation Committee held four meetings in fiscal 2015.met once and acted by unanimous written consent seven times. As of the Record Date,April 12, 2022, the Compensation Committee consisted of Deirdre Y. Gillespie, M.D.Brian Lian, Ph.D. (Chair), Sandford D. Smith and Wendell Wierenga, Ph.D., noneRichard W. Pascoe, neither of whom was an employee of the Companyours and each of whom met the independence requirements of the NASDAQ Marketplace.Nasdaq Rules and applicable rules of the SEC. The Compensation Committee acts under a written charter, a copy of which is posted on the Company’sour website at www.apricusbio.comwww.seelostherapeutics.com/corporate-governance/. The Company’sOur independent compensation consultants, as well as executive officers and management play important roles in making recommendations and formulating compensation plans for our employees, including the Named Executive Officers. Beginning 2018, the Compensation Committee determined to engage Radford, an AON Hewitt company, as its independent compensation consultant to provide compensation consulting services. Specifically,
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for 2020 and 2021, the Compensation Committee requested Radford to advise it on a variety of compensation related issues, including compiling, analyzing and presenting third-party survey data regarding the compensation of executives and directors at comparable companies. Radford did not provide any other services to us in 2020 or 2021 beyond its engagement as an advisor to the Compensation Committee on executive compensation and director compensation matters. After review, the Compensation Committee has determined that there is no conflict of interest resulting from retaining Radford currently or during the year ended December 31, 2021. In reaching these conclusions, the Compensation Committee considered the factors set forth in Exchange Act Rule 10C-1.
The Compensation Committee may delegate authority for day-to-day administration and interpretation of the Company’sour various compensation plans, including the selection of participants, the determination of award levels and the approval of award documents to our non-officer employees. However, the Compensation Committee may not delegate any authority under those plans for matters affecting the compensation and benefits of the Company’sour Named Executive Officers. For fiscal 2015, the Compensation Committee retained Radford, An Aon Hewitt Company (“Radford”), to assist the Compensation Committee in evaluating our executive compensation program to ensure competitive compensation standards with other comparable biotechnology and pharmaceutical companies. This process enables us to benchmark our job functions and job levels within our specific industry sector and geography, and to obtain competitive salary data, to maintain a competitive salary structure. Compensation recommendations and performance assessments of Named Executive Officers from the Company’sour Chief Executive Officer are also considered by the Compensation Committee in determining the total compensation packages for Named Executive Officers (excluding the Chief Executive Officer). The Chief Executive Officer is not present for any discussions relating to his compensation.
The Compensation Committee adopted an Equity Award Grant Policy on October 2, 2021, pursuant to which the Compensation Committee delegated to the Chief Executive Officer the power and authority, separately but concurrently with the power and authority of the Compensation Committee, to grant stock options, restricted stock awards, restricted stock units and stock-settled stock appreciation rights under the Company’s Amended and Restated 2012 Stock Long Term Incentive Plan (as amended, restated, supplemented or superseded, the “Equity Plans”) to our employees (other than executives and directors) on the terms and conditions approved by our Chief Executive Officer. The Equity Award Grant Policy also established the policy for the Company to follow when it grants stock options, stock appreciation rights, shares of restricted stock, restricted stock units, performance restricted stock units, performance-based units, stock-settled stock appreciation rights or other equity-based awards to our executives and employees pursuant to the Equity Plans.
Director Nominations and Stockholder Communications
Our Corporate Governance/Nominating Committee considers candidates for the Board submitted in writing to the Chair of the committee. Candidates may be submitted by our executive officers, current directors, search firms engaged by the Corporate Governance/Nominating Committee, and subject to the conditions described below, by a stockholder. Information with respect to any proposed candidate shall be provided in writing to the Chair of the Corporate Governance/Nominating Committee at Apricus Biosciences,Seelos Therapeutics, Inc., 11975 El Camino Real, Suite 300 San Diego, California 92130.Park Avenue, 2nd Floor, New York, New York 10022. A nominating stockholder shall provide evidence that he, she or it is a stockholder (including information relating to all shares deemed beneficially held by the nominating stockholder) and shall provide the name of the Board candidate(s), and such other information with respect to the nominee required under the rules and regulations of the SEC to be included in our proxy statement if such proposed candidate were to be included therein. In addition, the stockholder shall include a statement that the proposed candidate has no direct or indirect business conflict of interest with the Company,us, and otherwise meets our standards set forth below.
There are currently no specific, minimum or absolute criteria for Board membership. Candidates are evaluated based upon a number of factors, including but not limited to independence, knowledge, judgment, integrity, character, leadership, skills, education, experience, financial literacy, standing in the community and ability to foster a diversity of backgrounds and views and to complement the Board’s existing strengths. The Corporate Governance/Nominating Committee does not alter its evaluation practices with regardsregard to potential Board candidates recommended by a stockholder.
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The table below provides an enhanced disclosure regarding the diversity of our Board members and nominees. Each of the categories listed in the below table has the meaning as it is used in Nasdaq Rule 5605(f).
Board Diversity Matrix (As of April 12, 2022)
Board Size:
 
 
 
 
Total Number of Directors
5
 
Male
Female
Non-Binary
Gender
Undisclosed
Part I: Gender Identity
 
 
 
 
Number of directors based on gender identity
4
1
Part II: Demographic Background
 
 
 
 
African American or Black
Alaskan Native or Native American
Asian
1
Hispanic or Latinx
Native Hawaiian or Pacific Islander
White
3
1
Two or More Races or Ethnicities
LGBTQ+
Did not Disclose Demographic Background
Directors who are U.S. Military Veterans: 2
Any other stockholder communications intended for our management or the Board shall be submitted in writing to the Chair of the Corporate Governance/Nominating Committee (at theour Company’s address provided in this proxy statement)Proxy Statement) who shall determine whether to forward the communication, in his or her discretion and considering the identity of the submitting stockholder and the materiality and appropriateness of the communication.
Director Independence
Our Board has determined that each of Mr. Pascoe and Drs. XanthopoulosLian and Wierenga, and Messrs. Maier, Ray and SmithDalesandro met the definitions of independence under the NASDAQ MarketplaceNasdaq Rules and Section 10A-3 of the Securities Exchange Act as of 1934, as amended (the “Exchange Act”).the Record Date. Accordingly, all of our directors, other than our Chairman, Chief Executive Officer Mr. Pascoe,and President, Dr. Mehra, and Daniel J. O’Connor, are deemed to be independent.
Code of Ethics
We have adopted a Code of Ethics that applies to our Chief Executive Officer Chief Accounting Officer, and to all of our other officers, directors and employees. The Code of Ethics, as amended and restated, is available on the Corporate Governance section of the Investors page on our website at www.apricusbio.comwww.seelostherapeutics.com/corporate-governance/. We intend towill disclose future amendments to, or waivers from, certain provisions of our codeCode of ethics,Ethics, if any, on the above website within four business days following the date of such amendment or waiver. Information contained on, or that can be accessed through, our website is not intended to be incorporated by reference into this Proxy Statement, and references to our website address in this Proxy Statement are inactive textual references only.
Board’s Role in Risk OversightBoard Leadership Structure
Our Bylaws and corporate governance guidelines do not requireboard believes that our Chief Executive Officer, Dr. Mehra, is best situated to serve as Chairman of the Board because he is the director who is most familiar with our business and industry, possesses detailed and in-depth knowledge of the issues, opportunities and challenges facing us and is therefore best positioned to develop agendas that ensure that the Board’s time and attention are focused on the most critical matters. Our independent directors bring experience, oversight and expertise from outside the Company and industry, while the Chief Executive Officer positions be separate. Nevertheless,brings Company-specific experience and expertise. The Board believes that the positioncombined role of Chairman of the Board and Chief Executive Officer are separate positions. Mr. Pascoefacilitates information flow between management and the Board, which is our current Chief Executive Officer and Dr. Xanthopoulos is our current Chairman of the Board.essential to effective governance. The Board believes that this governancedoes not currently have a lead independent director. Our Board will continue to periodically review our leadership structure provides a necessary degree of independence betweenand may make such changes in the Board and management.future as it deems appropriate.
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Board’s Role in Risk Oversight
Risk is inherent with every business, and how well a business manages risk can ultimately determine its success. We face a number of risks, including, but not limited to, risks relating to product candidate development, technological uncertainty, dependence on clients and collaborative partners, uncertainty regarding patents and proprietary rights, comprehensive government regulations, marketing or sales capability or experience, business integration and dependence on key personnel. Management is responsible for the day-to-day management of the risks we face, while our Board as a whole and through its committees, is responsible for the oversight of risk management. Our Board believes its administration of its risk oversight function has not affected its leadership structure.
Board oversight is conducted primarily through committees of the Board, including the Audit Committee, Compensation Committee and the Corporate Governance/Nominating Committee. However, the full Board has retained responsibility for general risk oversight. Our Board satisfies this responsibility, in part, through reports by each committee chairChair regarding the committee’s considerations and actions. The Board also has the responsibility of ensuring compliance with the risk management processes designed and implemented by management, which it satisfies through reports directly from the officersofficer responsible for oversight of particular risks within our Company. The Board believes that full and open communication between management and the Board is essential for effective risk management and oversight.


Compensation Committee Interlocks and Insider Participation
During the last completed fiscal year, no member of the Compensation Committee was a current or former officer or employee of theour Company. None of our executive officers served as a member of the Compensation Committeecompensation committee (or board of directors serving the compensation function) of another entity where such entity’s executive officers served on our Compensation Committee.Committee, except that Dr. Mehra has served as a member of the compensation committee of Larkspur Healthcare Acquisition Corp., a special purpose acquisition company, since December 2021, where its Chief Executive Officer, Daniel J. O’Connor, served as a member of our Compensation Committee until February 2022. None of our executive officers served as a director of another entity whose executive officers served on our Compensation Committee. Moreover, none of our executive officers served as a member of the compensation committee (or board of directors serving the compensation function) of another entity where such entity’s executive officers served on our Board.
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EXECUTIVE OFFICERS
As of the date of this proxy,April 12, 2022, our current executive officers and their respective ages and positions are set forth in the following table.
Name
Age
Position
Raj Mehra, Ph.D.
62
NameAgePosition
Richard W. Pascoe52
Chairman, Chief Executive Officer Secretary and DirectorPresident
Barbara Troupin, M.D., M.B.A.
Michael Golembiewski
48
50
Senior Vice President,
Chief MedicalFinancial Officer
Brian T. Dorsey47Senior Vice President, Chief Development Officer
Neil Morton40Senior Vice President, Chief Business Officer
Raj Mehra, Ph.D.Richard W. Pascoe, is our Chairman, Chief Executive Officer Secretary and a member of the Board.President. See “Election of Class II Directors - Class“Class II Directors Continuing in OfficerOffice until 2018”2024” above for a discussion of Mr. Pascoe’sDr. Mehra’s business experience.
Michael GolembiewskiBarbara Troupin, M.D., M.B.A. has beenserved as our Senior Vice President, Chief MedicalFinancial Officer since December 2014. Dr. Troupin has held various senior management roles with VIVUS, Inc. in medical affairs and clinical development from 2006 until 2014. In these roles, Dr. Troupin was the lead clinician for the Phase 3 program for Qsymia, was the lead contributor for all medical review of the Qsymia New Drug Application and was the lead medical presenter at the successful Qsymia FDA Advisory Committee Meeting.September 2021. Prior to this, Dr. Troupin held Medical Director positions at the Profil Institute for Clinical Research and Radiant Research, both contract research organizations. Dr. Troupin received her M.D. from the University of Pennsylvania School of Medicine and her M.B.A. from the Wharton School of Business. In light of the Company’s decision to deprioritize its pipeline assets, Dr. Troupin and the Company entered into an employment transition agreement on April 13, 2016, pursuant to which Dr. Troupin’s employment with the Company will terminate effectiveMr. Golembiewski’s appointment as of May 31, 2016.
Brian T. Dorsey has been our Senior Vice President, Chief DevelopmentFinancial Officer, since December 2014. Mr. Dorsey has served in the pharmaceutical and biotechnology industries for over 20 years where he has provided high-level drug development, regulatory and QC/QA leadership of pharmaceutical candidates from early development to FDA approval. He has held various senior management roles with pharmaceutical companies, most recently at Pernix Therapeutics as Senior Vice President Pharmaceutical Development from April 2013 to September 2014. Mr. Dorsey held managerial positions of increasing responsibility at Somaxon Pharmaceuticals from 2005 to 2013, and before that at Baxter Bioscience and Pfizer Global Research and Development. Mr. Dorsey received his Master of Science in Executive Leadership and his B.A. in Chemistry from the University of San Diego.
Neil Morton has been our Senior Vice President, Chief Business Officer since April 2016. From March 2014 through March 2016, Mr. Morton served as our Vice President Business Development. Mr. Morton bringsof Finance from January 2019 to September 2021. Prior to joining the Company, Mr. Golembiewski served as Vice President of Finance at Agile Therapeutics, Inc., a successful track record in business development in specialty pharmaceuticals, most recently servingpublicly-traded biotechnology company, from November 2017 to June 2018. While at Agile Therapeutics, Inc., Mr. Golembiewski helped the company prepare for the potential launch of its first commercial product. Prior to joining Agile Therapeutics, Inc., Mr. Golembiewski served as the Executive DirectorVice President of Business Development at Auxilium PharmaceuticalsFinance, Principal Accounting Officer and Corporate Controller of Pernix Therapeutics Holdings, Inc., a publicly-traded specialty pharmaceutical company, from July 2009April 2015 to March 2014,November 2017, where he successfully led their effortsbuilt an accounting and finance team after the closure of the South Carolina office location. From June 2007 to April 2015, he held various roles of increasing responsibility in finance and accounting at NPS Pharmaceuticals, Inc., a publicly-traded biotechnology company acquired by Shire plc in 2015, with his last position as Executive Director, Corporate Controller, in which role he served from January 2014 to April 2015. While at NPS Pharmaceuticals, Inc., Mr. Golembiewski helped build the infrastructure that took the company from a pipeline of men’s health products.pre-clinical research and development company to a fully commercial and global rare disease company that received FDA approval for two orphan disease medicines. Prior to Auxiliumjoining NPS Pharmaceuticals, Inc., Mr. Golembiewski was the Corporate Controller for The Topps Company, Inc., from March 2006 to June 2007. The Topps Company was a publicly traded $500 million Trading Card and Candy Manufacturing company. He began his professional career in the biotechnology field with ImClone Systems Incorporated from May 1997 to March 2006, where he served in business developmentvarious roles with increasing responsibility, from Senior Accountant up to Director of Financial Reporting. Mr. Golembiewski is also the Chairman of the Board of The Connor G Foundation and marketing roles at King Pharmaceuticalshas served in this capacity since June 2019. The Connor G Foundation was established in 2019 as a nonprofit charity to benefit youth hockey, music and educational interests. Mr. Golembiewski has a Bachelor of Science degree in Accounting from July 2002 to April 2009, attaining the position of Senior Director, Commercial Development. Mr. Morton received his M.B.A. degree from the Babcock Graduate School of Management at Wake ForestRider University and his B.A. degreeis a Certified Public Accountant (not in biology from Bucknell University.public practice) in the State of Delaware.
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EXECUTIVE COMPENSATION
Compensation Discussion and Analysis
Executive Summary
The following compensation discussion and analysis describes the material elements of compensation earned in fiscal 2015 by each of the current or former executive officers identified below in the Summary Compensation Table who are referred to collectively as our “Named Executive Officers.” Our Named Executive Officers with respect
The following table sets forth the compensation paid by us during the years ended December 31, 2021 and 2020 to the fiscal year that ended on December 31, 2015 were Richard W. Pascoe, Chief Executive Officer, Secretary and Director, Barbara Troupin, M.D., M.B.A., Senior Vice President, Chief Medical Officer, and Brian T. Dorsey, Senior Vice President, Chief Development Officer.
Objectives of Our Executive Compensation Program
The Compensation Committee believes that executive compensation should be directly linked both to corporate performance and the achievement of objectives that are designed to increase stockholder value. In furtherance of this goal, the Compensation Committee has established the following objectivespersons who served as a foundation for compensation decisions:
provide a competitive total compensation package that generally targets the 50th percentile among our peer companies;
attract and retain highly qualified executives with the skills and experience required for the achievement of our business goals;
align compensation elements with the Company’s annual goals and long-term business strategies and objectives;
promote the achievement of key strategic and financial performance measures by linking short-term and long-term cash and equity incentives to the achievement of measurable corporate and individual performance goals; and
align executives’ incentives and rewards with the creation of stockholder value.
The Compensation Committee has historically focused on compensating executive officers, including Named Executive Officers, with three compensation components: base salary, annual cash incentives and equity-based compensation. The Compensation Committee believes that cash compensation in the form of base salary and an annual cash incentive provides our executives with short-term rewards for success in annual operations, and that long-term compensation through the award of stock options and other equity awards aligns the long term corporate performance objectives of management with those of our stockholders.
2015 Corporate Performance
Our Company’s 2015 accomplishments, guided by our Named Executive Officers (as defined below), included, among other things, the following:
initiated and completed enrollment in its fispemifene Phase 2b clinical trial for the treatment of symptomatic male secondary hypogonadism;
according to IMS Midas, over 633,000 Vitaros® units sold in Europe in 2015 through November;
Vitaros® monthly sales in Europe tracked on a 111,000 monthly unit run rate, which is expected to grow in both existing markets and new markets with additional launches throughout 2016 by our commercialization partners;
completed and reported top-line data on the Phase 2a clinical trial of RayVa for  Raynaud's Phenomenon secondary to scleroderma;
licensed the U.S. development and commercialization rights for Vitaros from Allergan plc; and
expanded Vitaros partnerships to include parts of Asia, Eastern Europe and Latin America.

2015 Compensation Programs and Decisions
In line with our executive compensation program’s emphasis on pay for performance, compensation awarded to our Named Executive Officers for 2015 reflected our corporate results and overall compensation philosophy:
Cash Compensation at or Below Median Level of Peers: The increases to our Named Executive Officers’ base salaries during 2015 were modest, and our Named Executive Officers’ target cash compensation remained at or below the median level relative to our peer group of companies, with base salaries remaining below the median.
Pay-for-Performance Annual Incentives: For 2015, our Company focused on certain key business development objectives and objectives related to the optimization of the Vitaros business, business development and operational goals. Our compensation program for 2015 was designed to support the Company’s focus on these areas and together


achievement in these areas represented 100% of our Named Executive Officers’ total bonus opportunity. Based on corporate performance in these areas during 2015, as summarized above, our Compensation Committee determined that our executive officers should be paid their bonuses at 75% of the targeted levels. In addition, our Compensation Committee determined that one-half of each of our during fiscal year 2021 (the “Named Executive Officer’s bonus would be paid in the form of restricted stock units (“RSUs”Officers), which will vest in February 2017, subject to the Named Executive Officer’s continued employment through such date. The annual bonuses awarded to our Named Executive Officers for 2015 are discussed below under “Annual Cash Incentive.”:
Continued Use of Performance-Based Stock Options Granted in 2015: Our Compensation Committee continued its practice of ensuring that a substantial portion of our Named Executive Officers’ total compensation is awarded in the form of long-term equity incentive awards. As in years past, the annual award was granted in the form of stock options, which are inherently performance-based as they provide value to our executives only if our stock price increases. For 2015, the Compensation Committee also granted a portion of the annual award in the form of performance-based stock options to Messrs. Pascoe, Martin and Cox, the vesting of which is tied to the achievement of key clinical objectives. The long-term equity incentive awards granted to our Named Executive Officers during 2015 are discussed below under “Equity Compensation.”
In light of the Company’s overall performance during 2015, the Compensation Committee believes that the Named Executive Officers’ 2015 compensation was appropriate.
Executive Compensation Best Practices
We regularly review and refine our executive compensation program to ensure that it continues to reflect practices and policies that are aligned with our pay-for-performance philosophy. The following practices and policies we believe are in line with current best practices for aligning executive and shareholder interests and sound corporate governance practices:
Name and Position(s)
Year
Salary
Bonus
Stock
Awards
Option
Awards(2)
Non-Equity
Incentive Plan
Compensation
All Other
Compensation(3)
Total
Raj Mehra, Ph.D.,
Chairman, Chief Executive Officer, President
2021
$522,500
$100,000
$10,344,000(4)
$4,360,685
$287,375
$11,242
$15,625,802
2020
$475,000
$3,502,863
$237,500
$11,734
$4,227,097
Michael Golembiewski
Chief Financial Officer(1)
2021
$281,667
$25,000
$720,461
$97,350
$12,917
$1,137,395
(1)
Compensation PracticeApricus Policy
Pay for PerformanceYESWe link pay to performance and stockholder interests by heavily weighting total target direct compensation to the achievement of strong stock price performance and a balanced mix of performance metrics established in advance by our Compensation Committee.
Annual “Say on Pay” VoteYESWe seek an annual non-binding advisory vote from our shareholders to approve the executive compensation programs disclosed in our Compensation Discussion and Analysis, tabular disclosure and related narrative in our proxy statement.
Independent Compensation ConsultantYESThe Compensation Committee retains an independent compensation consultant.
Annual Compensation Risk AssessmentYESEach year we perform an assessment of any risks that could result from our compensation plans and programs.
Limited PerquisitesYESWe provided very limited perquisitesIn connection with Mr. Golembiewski’s promotion to our Chief Financial Officer effective September 1, 2021, his base salary was increased from $275,000 to $295,000. In accordance with SEC guidance, compensation information for Mr. Golembiewski for fiscal year 2020 has not been included in this table because Mr. Golembiewski was not a named executive officer for fiscal year 2020.
(2)
Represents the grant date fair value of the option awards, calculated in accordance with Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) Topic 718, excluding the effect of estimated forfeitures. These figures do not reflect the amortized compensation expense or value received by the officer in the year indicated or that may be received by the officer with respect to such equity awards.
(3)
Our Named Executive OfficersOfficers’ All Other Compensation in 2015.
Guaranteed Base Salary Increases or BonusesNOWe do not guarantee base salary increases or provided guaranteed minimum annual bonuses.
Tax Gross-upsNOWe do not provide tax gross ups2020 and 2021 consist of our matching and profit-sharing contribution to our executives for “excess parachute payments.”
Repricing or Exchange of Underwater Stock OptionsNOWe prohibit option repricing without stockholder approval.
Single Trigger Change in Control SeveranceNOWe do not allow for single-trigger payment of cash severance benefits upon a change in control. Rather, we require double-trigger (or both a change in control and termination of executive’s employment) before any cash severance benefits are paid.retirement savings plan (401(k) Plan).
Roles in Determining Compensation
Compensation Committee
The Board has delegated to the Compensation Committee the responsibility to ensure that total compensation paid to our executive officers, including the Named Executive Officers, is consistent with our compensation policy and objectives.
The Compensation Committee draws on a number of resources, including input from executive officers, including the Chief Executive Officer, its independent compensation consultant and review of data on peer companies, to make decisions regarding the Company’s executive compensation program. The Compensation Committee retains discretion over base salary, annual cash bonus, equity compensation and other compensation considerations. The Compensation Committee relies upon the judgment of


its members in making compensation decisions, after reviewing the performance of the Company and carefully evaluating an executive’s performance during the year against established goals, operational performance and business responsibilities. In addition, the Compensation Committee incorporates judgment in the assessment process to respond to and adjust for the evolving business environment.
In the first quarter of each year, the Compensation Committee reviews the performance of each of our Named Executive Officers during the previous year. At this time the Compensation Committee also reviews our performance relative to the corporate performance objectives set by the Board for the year under review and makes the final annual incentive payment determinations based on our performance and the Compensation Committee’s evaluation of each Named Executive Officer’s performance for the year under review, if applicable. In connection with this review, the Compensation Committee also reviews and adjusts, as appropriate, annual base salaries for our Named Executive Officers and grants, as appropriate, additional stock option awards to our Named Executive Officers and certain other eligible employees for the then-current fiscal year.
During the fourth quarter of each year our Compensation Committee also reviews the corporate performance objectives for purposes of our annual incentive program for the following year, with such objectives historically being recommended to the full Board for approval. Our Chief Executive Officer, with the assistance and support of our human resources department, aids the Compensation Committee by providing annual recommendations regarding the compensation of all of our Named Executive Officers, other than himself. The Compensation Committee also, on occasion, meets with our Chief Executive Officer to obtain recommendations with respect to our compensation programs and practices generally. The Compensation Committee considers, but is not bound to accept, the Chief Executive Officer’s recommendations with respect to Named Executive Officer compensation. In the beginning of each year, our Named Executive Officers work with our Chief Executive Officer to establish their individual performance goals for the year, if applicable, based on their respective roles within the Company.
Chief Executive Officer
The Chief Executive Officer attends Compensation Committee meetings and works with the Compensation Committee Chair and the compensation consultant to (1) establish individual and Company performance goals for executive officers, excluding the Chief Executive Officer, at the beginning of each year and (2) develop compensation recommendations for executive officers, excluding the Chief Executive Officer, based upon individual and Company performance goals for the current year and individual merit. The Chief Executive Officer’s recommendations are then submitted to the Compensation Committee for review and consideration without the Chief Executive Officer present. The Chief Executive Officer is not present for deliberations and decisions made regarding his compensation.
Compensation Consultant
For 2015 the Compensation Committee retained the services of an external compensation consultant, Radford. The mandate of the consultant was to assist the Compensation Committee in its review of executive and director compensation practices, including the competitiveness of pay levels, executive compensation design and benchmarking with the Company’s peers in the industry. The Compensation Committee, after a review of the factors set forth in Section 10C-1 of the Exchange Act, determined that there was no conflict of interest in retaining Radford during 2015. Radford has not provided any other services to us during 2015 beyond their engagement as an advisor to the Compensation Committee.
Competitive Market Benchmarking
For purposes of setting 2015 executive compensation, the Compensation Committee worked with Radford to establish a list of peer companies for purposes of benchmarking our compensation practices. While, in general, the Compensation Committee strives to set target total target compensation for our Named Executive Officers to be at the 50th percentile among our peer group, the Compensation Committee does not establish compensation levels solely based on benchmarking. Instead, our Compensation Committee relies upon the judgment of its members in making compensation decisions, after reviewing our performance and carefully evaluating a Named Executive Officer’s performance during the year against established goals, leadership qualities, operational performance, business responsibilities, career with our company, current compensation arrangements and long-term potential to enhance stockholder value.
In addition, the Compensation Committee refers to compensation information for comparable companies in making its executive compensation decisions. The peer companies used in determining compensation actions in the 2015 fiscal year were selected by the Compensation Committee with input from Radford on the basis of their similarity to us in terms of competition for talent, phase of development or stage of commercialization (target range for peer group of Phase I, II, III lead candidate or later, including marketed drugs), market capitalization (less than $300 million), minimal product revenues and number of employees (less than 100). As of January 2015, we ranked at the 70th percentile of our 2015 peer group with respect to revenues and the 30th percentile of our 2015 peer group with respect to market capitalization.
The list of peer companies used in determining compensation actions in 2015 consisted of the following 21 publicly-traded companies in the pharmaceutical and biotechnology industries:


(4)
lAdamis PharmaceuticalslMediciNova
lAlexza PharmaceuticalslMEI Pharma
lCelladonlOcera Therapeutics
lCEL-SCIlPain Therapeutics
lChemoCentryxlRepros Therapeutics
lCytokineticslSophiris Bio
lEvoke PharmalStemline Therapeutics
lFate TherapeuticslSunesis Pharmaceuticals
lKaloBios PharmaceuticalslThreshold Pharmaceuticals
lLipocinelVical
lMast TherapeuticsRepresents the grant date fair value of a performance restricted stock unit award granted to Dr. Mehra on March 15, 2021, calculated in accordance with FASB ASC Topic 718, excluding the effect of estimated forfeitures. This figure does not reflect the amortized compensation expense or value received by Dr. Mehra in 2021 or that may be received by Dr. Mehra with respect to such award. On March 8, 2022, prior to its vesting, this award was voluntarily forfeited by Dr. Mehra and cancelled by the Company.
We expect that theNarrative Disclosure to Summary Compensation Committee will continue to review comparable company data in connection with setting the compensation we offer our Named Executive Officers to help ensure that our compensation programs are competitive and fair. Table
We strive to achieve an appropriate mix between equity incentive awards and cash payments in order to meet our objectives. Any apportionment goal is not applied rigidly and does not control our compensation decisions, and our Compensation Committee does not have any formal policies for allocating compensation between long-term and short-term compensation or cash and non-cash compensation. Because we are an early stage company, we generally pay a higher portion of compensation in the form of equity. The compensation levels of the Named Executive Officers reflect to a significant degree the varying roles and responsibilities of such executives. As a result of the Compensation Committee’s and the Board’s assessment of our Chief Executive Officer’s significant role and responsibilities within our Company, there are significant compensation differentials between him and our other Named Executive Officers.
Implementation of Objectives
In fiscal 2015, our executive compensation program consisted of the following forms of compensation, each of which are described below in greater detail:
base salary;
annual cash incentive;
equity compensation; and
employee benefit program.
Base Salary
Overview
In general, base salaries for our Named Executive Officers are approved by the Compensation Committee and are initially established through arm’s length negotiation at the time the executive is hired, taking into account such executive’s qualifications, experience, prior salary and market pay levels. Base salaries of our Named Executive Officers are approved and reviewed annually by our Compensation Committee and adjustments to base salaries are based on the scope of an executive’s responsibilities, individual contribution, prior experience and sustained performance. Decisions regarding salary increases may take into account an executive officer’s current salary, equity ownership, and the amounts paid to an executive officer’s peers inside our companyCompany by conducting an internal analysis, which compares the pay of an executive officer to other members of the management team. Base salaries are also reviewed in the case of promotions or other significant changes in responsibility. Base salaries are not automatically increased if the Compensation Committee believes that other elements of the Named Executive Officer’sOfficers’ compensation are more appropriate in light of our stated objectives. This strategy is consistent with our intent of offering compensation that is both cost-effective, competitive and contingent on the achievement of performance objectives.
InEffective January 2015, the Compensation Committee approved a1, 2021, Dr. Mehra’s base salary increase forwas increased from $475,000 to $522,500. In connection with Mr. Pascoe of 7%Golembiewski’s promotion to the level shown in the table below. Thisour Chief Financial Officer, effective September 1, 2021, his base salary increase was intendedincreased from $275,000 to bring Mr. Pascoe’s base salary closer in line with the 50th percentile of our peer companies (although it remained below such level even after the increase) and to reward strong performance during 2014.
The base salaries for Dr. Troupin and Mr. Dorsey were set by the Compensation Committee in connection with their commencement of employment in December 2014 and are also below the 50th percentile of our peer companies.


On March 15, 2016, the Compensation Committee approved base salary increases for Mr. Pascoe, Dr. Troupin and Mr. Dorsey, effective April 1, 2016.The following table shows the 2015 salaries for our Named Executive Officers as well as the increased salaries for fiscal 2016:
    Annual Base Salary
Name Title 2016 2015
Richard W. Pascoe Chief Executive Officer, Secretary and Director $487,396
 $473,200
Barbara Troupin, M.D., M.B.A. Senior Vice President, Chief Medical Officer $334,750
 $325,000
Brian T. Dorsey Senior Vice President, Chief Development Officer $319,300
 $310,000
$295,000.
Annual Cash Incentive
Overview
The CompanyWe also providesgenerally provide executive officers with annual performance-based cash bonuses, which are specifically designed to reward executives for our overall Company performance in a given year. Corporate goals are established by the Compensation Committee with input from senior management and approved by the full Board. The target annual cash bonus amounts relative to base salary vary depending on each executive’s accountability, scope of responsibilities and potential impact on the Company’s performance.
The Compensation Committee considers the Company’sour overall performance for the preceding fiscal year in deciding whether to award a bonus and, if one is to be awarded, the amount of the bonus. The annual cash bonus for each
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executive officer is based 100% on our overall Company performance. The Compensation Committee retains the ability to apply discretion in making adjustments to the final bonus payouts.
At The evaluation of our performance for 2021 bonus purposes was based on a qualitative evaluation for the endNamed Executive Officers after the start of eachthe fiscal year, corporate performance is measured and a percentage of target is fixed, which then determines which annual bonus incentives are to be paid to executive officers.year. For fiscal year 2015, the2021, Dr. Mehra’s target bonus percentage was 50% of his base salary and Mr. Golembiewski’s target bonus percentage was 30% of his base salary. The Compensation Committee determined the percentage attainment of performance goals for the Company to be 75%. Based on this percentage of Companyevaluated both Dr. Mehra’s and Mr. Golembiewski’s performance and becauseour performance during 2021, including the Named Executive Officers’ bonuses are weighted 100% based on overall Company performance,completion of two equity financings and one debt financing in 2021, the 2015 bonuses for Mr. Pascoe,progress of our SLS-002, SLS-004, SLS-005 and SLS-007 programs, the acquisition of certain new product candidates and the entry into certain licensing and research agreements, and determined that Dr. Troupin,Mehra and Mr. Dorsey were equal to 75%Golembiewski should each be paid a bonus at 110% of their respective target bonuses.the targeted level.
The following table sets forth the target bonus for each of the Named Executive Officers for fiscal 20152021 and the resulting incentive payout, based on the level of achievement of the 20152021 corporate goals:
Name
Title(s)
Fiscal Year 2021
Incentive Bonus
Rate at Target
2021 Evaluation
of Company
Performance
Final Ratio
Incentive Bonus
as a Percentage
of Base Salary as
in effect as of
12/31/2021
Fiscal 2021
Incentive
Bonus
Award
Raj Mehra, Ph.D.
Chairman, Chief Executive Officer and President
50%
110%
55%
$287,375
Michael Golembiewski
Chief Financial Officer
30%
110%
33%
$97,350
Success Cash Bonus
Name Title Fiscal Year 2015 Incentive Bonus Rate at Target 2015 Evaluation of Company Performance 
Final Ratio
Incentive Bonus/
Base
 Portion of Fiscal 2015 Incentive Bonus Award Paid in Cash (1)
Richard W. Pascoe Chief Executive Officer, Secretary and Director 50% 75% 38% $88,555
Barbara Troupin, M.D., M.B.A. Senior Vice President, Chief Medical Officer 40% 75% 30% $48,750
Brian T. Dorsey Senior Vice President, Chief Development Officer 40% 75% 30% $46,500
(1)Represents the portion of the 2015 bonus paid in cash to the above officers. At the discretion of the Company’s Compensation Committee, RSUs were granted in satisfaction of one-half of the executives’ 2015 bonus awards. The RSUs were granted on March 15, 2016 under the Company’s 2012 Stock Long Term Incentive Plan. The number of RSUs issued to each executive was determined by dividing the portion of the annual bonus to be paid in the form of RSUs (Mr. Pascoe: $88,555; Dr. Troupin: $48,750; and Mr. Dorsey: $46,500) by the closing price of the Company’s common stock on the date of grant ($1.11). The RSUs will vest on February 15, 2017, subject to the executive’s continued employment with the Company through such vesting date.
AchievementBased on our significant and sustained efforts advancing our open-label study of GoalsSLS-002 and Relationship to Compensation Awarded
The evaluation of Company performance for 2015 bonus purposes was based on the achievement, or failure to achieve, a set of weighted performance goals. The Compensation Committee assessed the overall Company goals and determined a weighted achievement of 75%. The Company’s 2015 performance goals included (1) establishment of RayVa proof-of-concept (weighted


at 20%), (2) initiation of the fispemifene development program (weighted at 40%), (3) ending 2015 with one year of operating capital (weighted at 20%), and (4) several key initiatives around the further development and commercialization of Vitaros (20% weighting). In awarding a 75% achievement level for 2015,positive topline study data results announced, the Compensation Committee approved cash bonuses to certain employees in May 2021. A payment of $100,000 was awarded partial credit for the first objective asto Dr. Mehra and a resultpayment of patient enrollment in the Phase 2b clinical trial, full credit for the second objective, partial credit for the third objective as a result of the operating capital on-hand at the end of the year and partial credit for the fourth objective as a result of Vitaros revenues and certain processes$25,000 was awarded to further enhance the product’s stability profile.Mr. Golembiewski.
Equity Compensation
Overview
The Compensation Committee considers equity incentives to be important in aligning the interests of our executive officers with those of our stockholders. As part of our pay-for-performance philosophy, the Company’sour compensation program tends to emphasize the long-term equity award component of total compensation packages paid to our executive officers.
Because vesting is based on continued employment, our equity-based incentives also encourage the retention of our Named Executive Officers through the vesting period of the awards. In determining the size of the long-term equity incentives to be awarded to our Named Executive Officers, we take into account a number of internal factors, such as the relative job scope, the value of existing long-term incentive awards, individual performance history, prior contributions to us and the size of prior grants. For 2015, while our Compensation Committee reviewed competitive market data prepared by Radford in connection with its grant of long-term equity incentive awards to the Named Executive Officers, such awards were not determined by reference to any specific target level of compensation or benchmarking. Based upon these factors, the Compensation Committee determines the size of the long-term equity incentives at levels it considers appropriate to create a meaningful opportunity for reward predicated on the creation of long-term stockholder value.
To reward and retain our Named Executive Officers in a manner that best aligns employees’ interests with stockholders’ interests, we usehave used stock options as the primary incentive vehicles for long-term compensation.compensation and may in the future use restricted stock unit awards. We believe that stock options and restricted stock unit awards are an effective tooltools for meeting our compensation goal of increasing long-term stockholder value by tying the value of the stock options to our future performance. Because employees are able to profit from stock options only if our stock price increases relative to the stock option’s exercise price, we believe stock options provide meaningful incentives to employees to achieve increases in the value of our stock over time.
We usehave used stock options and restricted stock unit awards to compensate our Named Executive Officers both in the form of initial grants in connection with the commencement of employment and annual refresher grants. Annual grants of optionsequity awards are typically approved by the Compensation committeeCommittee during the end of the last quarter, or the beginning of the first quarter, of each year. While we intend that the majority of stock optionequity awards to our employees be made pursuant to initial grants or our annual grant program, the Compensation
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Committee retains discretion to make stock optiongrant equity awards to employees at other times, including in connection with the promotion of an employee, to reward an employee, for retention purposes or for other circumstances recommended by management or the Compensation Committee. In 2021, we granted: (i) options to purchase 1,945,000 shares of our Common Stock under our Amended and Restated 2012 Stock Long Term Incentive Plan, as amended (the “Amended and Restated 2012 Plan”), to our employees, including grants of options to purchase 1,340,000 shares of our Common Stock to our Named Executive Officers; (ii) options to purchase 106,000 shares of our Common Stock under the Amended and Restated 2012 Plan to our non-employee directors pursuant to our non-employee director compensation policy; and (iii) options to purchase 150,000 shares of our Common Stock under our 2019 Inducement Plan (the “Inducement Plan”) to certain new employees. Except for the performance restricted unit award granted to Dr. Mehra discussed below, we did not grant any restricted stock unit awards in 2021. In order to compensate our executive officers fairly for the time, effort and accountability required and align their interests with those of our stockholders, the Compensation Committee approved an annual grant of options to purchase 1,150,000 shares and 190,000 shares of our Common Stock to Dr. Mehra and Mr. Golembiewski, respectively, in 2021. In addition, our Compensation Committee granted a performance restricted stock unit award (the “PRSU”) under the Amended and Restated 2012 Plan for an aggregate amount of 2,400,000 shares of our Common Stock to Dr. Mehra in 2021. The shares subject to the PRSU were scheduled to vest upon the achievement of one or more of requisite milestones during the four-year period from the date of grant at a rate of 20% per milestone, provided that in no event would any of the PRSUs vest before (a) March 15, 2022 and (b) at least three of the five requisite milestones have been achieved, and vesting of the PRSU was subject to Dr. Mehra’s continued employment through the applicable vesting date. On March 8, 2022, the PRSU was voluntarily forfeited by Dr. Mehra and cancelled by the Company.
The exercise price of each stock option grant is the fair market value of our Common Stock on the grant date. Time-based stock option awards granted to our Named Executive Officers generally vest over a four-year period as follows: 25% of the shares underlying the option vest on the first anniversary of the date of the vesting commencement date and the remainder of the shares underlying the option vest in equal monthly installments over the remaining 36 months thereafter. From time to time, our Compensation Committee may, however, determine that a different vesting schedule is appropriate. Commencing in 2014, our Compensation Committee also granted performance-based stock option agreements to our Named Executive Officers as a part of the annual grant program to further tie executive compensation with long-term stockholder interests and Company performance. For a description of certain accelerated vesting provisions applicable to such options, see “Payments Upon Termination or Change in Control” below. We do not have any stock ownership requirements for our Named Executive Officers.
2015 Awards Granted- Time-Based and Performance-Based Stock Options
In January 2015, the Compensation Committee awarded annual stock option awards to Mr. Pascoe, Dr. Troupin, and Mr. Dorsey based on its review of the foregoing factors and comparable company information. These awards are described in detail in the “Grants of Plan-Based Awards Table” below. Of the stock options granted to Mr. Pascoe, Dr. Troupin and Mr. Dorsey, 33.3%, 100% and 100%, respectively, were subject to performance-based vesting (calculated by comparing the number of shares of the Company’s common stock subject to performance-based options as compared to the total number of shares of the Company’s common stock subject to all of the options granted to our Named Executive Officers). The stock options that are subject to time-based vesting are subject to our standard four-year vesting schedule described above. The stock options that are subject to performance-based vesting are subject to three performance objectives, each of which was designed to align the Named Executive Officer’s interests and long-term equity compensation opportunities to key corporate performance objectives:
LPO in Phase 3 Program. Initiation of last patient out in a Phase 3 development program before December 31, 2017. The awards will vest in full upon achievement of goal.


Fispemifene Phase 2b. Completion of fispemifene Phase 2b clinical trial in secondary hypogonadism by June 30, 2016, the results of which support moving into Phase 3 trials. The awards will vest in full upon achievement of goal.
RayVa NDA. Completion of the filing of an NDA for RayVa occurs on or before December 31, 2017. The awards will vest in full upon achievement of goal.
The Compensation Committee’s determination regarding each Named Executive Officer’s annual award amount was not based on any quantifiable factors, but instead was based on the Compensation Committee’s subjective analysis of the award levels the Compensation Committee deemed appropriate for each executive in light of various factors, including the fact that each executive’s base salary remained below the 50th percentile for the Company’s peer group for 2015. The final award levels, however, were entirely based on the Compensation Committee’s subjective analysis of these general factors and internal pay equity considerations.
2014 Awards- Certain Achieved and Vested in 2015
In February 2014, Mr. Pascoe was granted stock options subject to performance-based vesting. These performance-based stock options were subject to three performance objectives, each of which was designed to align his interests and long-term compensation opportunity to key corporate objectives:
Shareholder Return. Relative shareholder return of Company common stock measured against the NASDAQ Biotechnology Index (“NBI”). Apricus return must exceed NBI return over the period from grant date through December 31, 2015. The stock option will vest as to 50% of the shares subject to the option on achievement of the performance goal and then vest monthly thereafter over the next two years. The performance objective for these options was not achieved and, as a result, these options were forfeited on December 31, 2015.
Pipeline Build. Initiation by December 31, 2015 of at least two Phase 2 (or later) clinical studies of Board-approved assets. Vesting with respect to 25% of the shares subject to the option to be effective on the first patient enrolled in each of the two trials, with another 50% of the shares (25% per study) subject to the option to vest monthly over a two-year period following the enrollment of the first patient.
In December 2014, the Company announced its first patient enrollment in its Phase 2a clinical trial for RayVa in patients with Raynaud’s Phenomenon. As a result, 25% of the shares subject to this option vested in the fourth quarter of 2014 and a portion will continue to vest monthly until fully vested in December 2016.
In May 2015, the Company announced its first patient enrollment in its Phase 2b clinical trial for fispemifene in men with symptomatic secondary hypogonadism. As a result, 25% of the shares subject to this option vested in the second quarter of 2015 and a portion will continue to vest monthly until fully vested in May 2017.
Room Temperature Product. Secure first approval by December 31, 2016 of room temperature formulation/device for Vitaros. The stock option will vest as to 50% of the shares subject to the option on achievement of the performance goal and then vest monthly thereafter over the next two years.
The foregoing performance objective has not yet been achieved and these options remain eligible to vest.
Employee Benefit Program
Executive officers, including theOur Named Executive Officers are eligible to participate in all of our employee benefit plans, including medical, dental, vision, group life, disability and accidental death and dismemberment insurance, in each case on the same basis as other employees, subject to applicable law. We also provide vacation and other paid holidays to all employees, including executive officers. These benefit programs are designed to enable us to attract and retain our workforce in a competitive marketplace. Health, welfare and vacation benefits ensure that we have a productive and focused workforce through reliable and competitive health and other benefits.
Our retirement savings plan (401(k) Plan) is a tax-qualified retirement savings plan, pursuant to which eligible employees can begin to participate immediately upon employment. The 401(k) Plan elective deferrals and employer contributions are subject to compensation limitations and annual maximum contribution limits as governed by Internal Revenue Service. Employees are eligible to defer up to 100% of compensation and the Company makeswe make safe harbor matching contributions of a 100% match of the first 3% of compensation contributed, then a 50% match of the next 2% of compensation contributed.
Hedging and Pledging Prohibitions
Our insider trading policy prohibits our directors, officers (including our executive officers), employees and consultants, including those who serve in such capacities with any of our subsidiaries (“Persons Covered”), from engaging in short sales of our securities and from engaging in transactions in publicly traded options, such as puts, calls and other derivative securities, on an exchange or in any other organized market. Without first obtaining pre-clearance of the transaction from our Insider Trading Compliance officer, the Persons Covered may not engage in any transaction involving our securities, including an option exercise, or a gift, loan, pledge or hedge, contribution to a trust or any other transfer. Our insider trading policy also applies to the family members who reside with the Persons Covered, anyone else who lives in their household and any family members who do not live in their household but whose transactions in our securities are directed by the Persons Covered or are subject to their influence or control.
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Outstanding Equity Awards as of December 31, 2021
Our Named Executive Officers held the following outstanding equity awards as of December 31, 2021:
 
Option Awards
Stock Awards
Name
Grant Date
Number of
Securities
Underlying
Unexercised
Options
Exercisable
(#)
Number of
Securities
Underlying
Unexercised
Options
Non-Exercisable
(#)
Option
Exercise Price
($)
Option
Expiration
Date
Number of
Shares or
Units of
Stock That
Have Not
Vested (#)
Market
Value of
Shares or
Unites of
Stock That
Have Not
Vested ($)
Raj Mehra Ph.D.
January 6, 2020(1)
350,270
380,730
$1.42
1/6/2030
 
June 11, 2020(2)
855,847
1,426,415
$1.08
6/11/2030
 
March 15, 2021(3)
1,150,000
$4.31
3/15/2031
 
March 15, 2021(4)
2,400,000
$3,912,000
Michael Golembiewski
February 26, 2019(5)
45,572
16,928
$2.20
2/26/2029
 
January 6, 2020(1)
47,916
52,084
$1.42
1/6/2030
 
June 11, 2020(2)
117,078
195,133
$1.08
6/11/2030
 
March 15, 2021(3)
190,000
$4.31
3/15/2031
(1)
1/4th of the shares subject to the option vested on January 6, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.
(2)
1/4th of the shares subject to the option vested on June 11, 2021, and 1/48th of the shares subject to the option vest monthly thereafter.
(3)
1/4th of the shares subject to the option vested on March 15, 2022, and 1/48th of the shares subject to the option vest monthly thereafter.
(4)
The shares subject to this PRSU were scheduled to vest upon achieving requisite milestones during the four-year period from March 15, 2021, at a rate of 20% per milestone, provided that in no event would any of the PRSUs vest before (a) March 15, 2022 and (b) at least three of the five requisite milestones have been achieved, and vesting of the PRSU was subject to Dr. Mehra’s continued employment through the applicable vesting date. On March 8, 2022, this PRSU was voluntarily forfeited by Dr. Mehra and cancelled by the Company.
(5)
1/4th of the shares subject to the option vested on January 27, 2020, and 1/48th of the shares subject to the option vest monthly thereafter.
Payments Uponupon Termination or Change Inin Control
We have entered into employment agreements with each of theour Named Executive Officers. These agreements set forth the individual’s base salary, annual incentive opportunities, equity compensation and other employee benefits, which are described in this Executive Compensation section. All employment agreements provide for “at-will” employment, meaning that either party can terminate the employment relationship at any time, although our agreements with our Named Executive Officers provide that


they the applicable Named Executive Officer would be eligible for severance benefits in certain circumstances following a termination of employment without cause. Our Compensation Committee approved the severance benefits to mitigate certain risks associated with working in a biopharmaceutical company at our current stage of development and to help attract and retain qualified executives. The severance benefits upon termination or change in control for our Named Executive Officers who were employed by the Company on December 31, 2015 are described in the “Potential Payments Upon Termination or Change in Control” table.Officers.
Richard W. PascoeRaj Mehra, Ph.D. Employment Agreement
On March 18, 2013,20, 2019, we entered into an employment agreement with Richard W. Pascoe when he became theRaj Mehra, Ph.D., pursuant to which Dr. Mehra previously served as our President, Chief Executive Officer, Chairman of the Company. TheBoard and Interim Chief Financial Officer. On January 10, 2022, we entered into an amended and restated employment agreement with Dr. Mehra (the “CEO Employment Agreement”), which provides that Dr. Mehra will continue to serve as our President and Chief Executive Officer. Dr. Mehra’s initial annual base salary is $561,688 and he will be eligible to receive an initial annual performance bonus of 50% of his base salary. Dr. Mehra’s employment is for an initial term of three years from March 20, 2022 and is on an “at will” basis.
Pursuant to the CEO Employment Agreement, if Mr. Pascoe’s employment ends dueDr. Mehra is terminated by us without cause or by Dr. Mehra for good reason (a “Covered Termination”) outside of the period commencing three months prior to an involuntary termination, as such term is defineda change in his agreement, he would receive, in a lump sum payment,control and ending 12 months after a change in control (a “Change in Control Period”), we will pay to Dr. Mehra an amount equal to the sum of his annual base salary and the annual bonus earned by Dr. Mehra for the fiscal year immediately preceding the fiscal year in effect onwhich the date termination occurs, and a pro-rata portion
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of termination, any unpaidhis earned annual bonus for the calendar year preceding his termination, to the extent that the criteria for the bonus has been met, the average of any bonus paid during each of the three most recent fiscal years prior to termination, full acceleration and vesting of his unvested equity awards, and reimbursement for the cost of continuation of health insurance benefits provided to him immediately prior to the termination (as provided under Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”) or other applicable law) for 12 months.
If Mr. Pascoe’s employment is terminated in connection with his death or a permanent disability, Mr. Pascoe or his estate is entitled to a pro rata bonus for the calendar year in which suchthe termination occurs, equal tooccurs. Additionally, the bonus he would have received, to the extent all criteria for such a bonus have been met (with the exceptionvesting of the requirement that he be employed on the date the bonus is to be paid), for the calendar year of termination multiplied by a fraction, the numerator of which is the number of days in such year preceding and including the date of termination, and the denominator of which is 365. Such pro-rata bonus shall be paid at the same time as the bonus would have been paid had Mr. Pascoe remained employed by the Company through the date of payment, but in any event, not later than March 15 of the calendar year following the calendar year for which the bonus is payable. Mr. Pascoe is also entitled to receive any unpaid bonus for the calendar year preceding his termination, to the extent that all criteria for such bonus have been met (with the exception of the requirement that he be employed on the date the bonus is to be paid). Such bonus shall be paid at the same time as the bonus would have been paid had he remained employed by the Company through the date of payment. Additionally, all of his outstanding but unvested equity awards that are scheduled to vest solely subject to continued service or employment shall vest immediately and the expiration date for allaccelerate so that such equity awards shall be extended so that they expire one year after termination duevested to death or permanent disability.
In the event that Mr. Pascoe sufferssame extent as if Dr. Mehra had provided an involuntary termination within the 12-month period following the effective dateadditional 12 months of a change of control, then in addition to all salary and bonuses accrued as ofservice from the date of his termination hetermination. We will also be entitledeither continue to severance benefits. These include (i)provide Dr. Mehra and his dependents coverage under our group health plan at our sole expense or reimburse Dr. Mehra for such coverage for 12 months from the Company shalldate of termination.
The CEO Employment Agreement also provides that if Dr. Mehra experiences a Covered Termination during a Change in Control Period, we will pay to Mr. Pascoe in one lump sumDr. Mehra an amount equal to 1.5 times the greatersum of (A) 12 months ofhis annual base salary and the salary that he was receivingannual bonus earned by Dr. Mehra for the fiscal year immediately prior topreceding the fiscal year in which the termination or (B) 12 monthsoccurs, and a pro-rata portion of the salary that he was receiving immediately prior to the change of control; (ii) the Company shall pay to Mr. Pascoe in one lump sum (A) any unpaidhis earned annual bonus for the calendarfiscal year precedingin which the termination occurs. Additionally, the vesting of any outstanding equity awards that are scheduled to vest solely subject to continued service or employment shall accelerate so that such awards shall be fully vested. We will also either continue to provide Dr. Mehra and his termination, to the extent that all criteriadependents coverage under our group health plan at our sole expense or reimburse Dr. Mehra for such bonus have been met (with the exception of the requirement that he be employed on the date the bonus is to be paid), plus (B) 100% of the average bonus paid by the Company to himcoverage for services during each of the three most recent fiscal years (or such shorter period of time during which he was eligible for a bonus) prior to18 months from the date of the termination; (iii) full acceleration of the vesting of all equity awards held by Mr. Pascoe at the time of the termination, including any options, restricted stock, RSUs or other awards, and (iv) reimbursement for the cost of continuation of health insurance benefits provided to him immediately prior to the termination pursuant to the terms of COBRA or other applicable law for a period continuing until the earlier of 12 months following the termination or the date upon which he is no longer eligible for such COBRA or other benefits under applicable law. In addition, the performance-based stock options granted to Mr. Pascoe in February 2014 and 2015 will vest upon the occurrence of a change in control.termination.
If he is terminated for cause at any time or resigns under circumstances that do not constitute an involuntary termination, then Mr. Pascoe shall not be entitled to receive payment of any severance benefit or any continuation or acceleration of stock option vesting. He will receive payment for all salary accrued as of the date of termination of employment.
Barbara Troupin, M.D., M.B.A.Michael Golembiewski Employment Agreement
On December 12, 2014,January 16, 2019, we entered into an employment agreement with Barbara Troupin, M.D. On April 13, 2016, we entered into anMichael Golembiewski (the “Golembiewski Employment Agreement”), pursuant to which Mr. Golembiewski initially served as our Vice President of Finance. The agreement provides for “at-will” employment transition agreement with Dr. Troupin that superseded her employment agreement. The employment agreement provided that if Dr. Troupin’s employment ended due to an involuntary termination, as such term is defined in her employment agreement, she would have received, in a lump sum payment, 12 monthsand sets forth certain agreed upon terms and conditions of heremployment. Mr. Golembiewski’s initial annual base salary was $200,000 and he was eligible to receive an initial discretionary annual bonus in effect on the datean amount up to 30% of termination, any unpaid bonus for the calendar year preceding her termination, to the extent that the criteria for the bonus had been met, the average of any bonus paid during each of the three most recent fiscal years prior to termination (with any bonus for a partial year of employment annualized for such purpose), full acceleration and vesting of her unvested equity awards, and reimbursement for the cost of continuation of health insurance benefits provided to her immediately prior to the termination (as provided under COBRA or other applicable law) for 12 months.


The employment agreement provided that if Dr. Troupin’s employment was terminated inhis base salary. In connection with her death or a permanent disability, Dr. Troupin or her estate would have been entitledMr. Golembiewski’s promotion to a pro rata target bonus for the calendar year in which such termination occurs. Dr. Troupin would also have been entitledour Chief Financial Officer, effective September 1, 2021, his base salary was increased to receive any accrued but unpaid bonus for the calendar year preceding her termination,$295,000. Effective January 1, 2022, Mr. Golembiewski’s base salary was further increased to the extent that all criteria for such bonus had been met (with the exception of the requirement that she be employed on the date the bonus is to be paid). Such bonus amounts would have been paid in cash in a lump sum following the effectiveness of a general release of claims (or, in the event of her death, within five days following the date of death). Additionally, all of her outstanding but unvested equity awards would have vested immediately and the expiration date for all such equity awards would have been extended so that they expired one year after termination due to death or permanent disability.
Under the employment agreement, in the event that Dr. Troupin suffered an involuntary termination within the 12-month period following the effective date of a change of control, then in addition to all salary and bonuses accrued as of the date of her termination she would have also been entitled to severance benefits. These include (i) the Company would have paid to Dr. Troupin in one lump sum an amount equal to the greater of (A) 12 months of the salary that she was receiving immediately prior to the termination or (B) 12 months of the salary that she was receiving immediately prior to the change of control; (ii) the Company would have paid to Dr. Troupin in one lump sum (A) any unpaid bonus for the calendar year preceding her termination, to the extent that all criteria for such bonus had been met (with the exception of the requirement that she be employed on the date the bonus is to be paid), plus (B) 100% of the average bonus paid by the Company to her for services during each of the three most recent fiscal years (or such shorter period of time during which she was eligible for a bonus) prior to the date of the termination; (iii) full acceleration of the vesting of all equity awards held by Dr. Troupin at the time of the termination, including any options, restricted stock, RSUs or other awards, and (iv) reimbursement for the cost of continuation of health insurance benefits provided to her immediately prior to the termination pursuant to the terms of COBRA or other applicable law for a period continuing until the earlier of 12 months following the termination or the date upon which she is no longer eligible for such COBRA or other benefits under applicable law. In addition, the performance-based stock options granted to Dr. Troupin in February 2015 would have vested upon the occurrence of a change in control.
Under the employment agreement, if she was terminated for cause at any time or voluntarily resigns under circumstances that do not constitute an involuntary termination, then Dr. Troupin would not have been entitled to receive payment of any severance benefit or any continuation or acceleration of stock option vesting. She would have received payment for all salary accrued as of the date of termination of employment.$317,125.
Pursuant to the employment transition agreement, which superseded the employment agreement, Dr. Troupin’s employment with the Company will terminate effective as of May 31, 2016. Pursuant to the employment transition agreement, following her termination of employment and subject to her execution of a general release of claims, Dr. Troupin will be entitled to receive certain severance benefits, including the payment of her annual base salary, an amount equal to her annual bonus for 2015, six months of continued health benefits at Company expense, and full acceleration of all of her outstanding equity awards.
Brian T. Dorsey
On December 1, 2014, we entered into an employment agreement with Brian T. Dorsey. The agreement provides thatGolembiewski Employment Agreement, if Mr. Dorsey’s employment ends due to an involuntary termination, as such term is defined in his agreement, he would receive, in a lump sum payment, 12 months of his annual base salary in effect on the date of termination, any accrued but unpaid bonus for the calendar year preceding his termination (with any bonus for a partial year of employment annualized for such purpose), to the extent that the criteria for the bonus has been met, the average of any bonus paid during each of the three most recent fiscal years prior to termination, and full acceleration and vesting of his unvested equity awards, and reimbursement for the cost of continuation of health insurance benefits provided to him immediately prior to the termination (as provided under COBRA or other applicable law) for 12 months.
If Mr. Dorsey’s employmentGolembiewski is terminated in connection with his death or a permanent disability, Mr. Dorsey or his estate is entitled to a pro rata target bonus for the calendar year in which such termination occurs. Mr. Dorsey is also entitled to receive any accrued but unpaid bonus for the calendar year preceding his termination, to the extent that all criteria for such bonus have been met (with the exception of the requirement that he be employed on the date the bonus is to be paid). Such bonus amounts shall be paid in cash in a lump sum following the effectiveness of a general release of claims (or, in the event of his death, within five days following the date of death). Additionally, all of his outstanding but unvested equity awards shall vest immediately and the expiration date for all such equity awards shall be extended so that they expire one year after termination due to death or permanent disability.
In the event that Mr. Dorsey suffers an involuntary termination within the 12-month period following the effective date of a change of control, then in addition to all salary and bonuses accrued as of the date of his termination he will also be entitled to severance benefits. These include (i) the Company shall pay to Mr. Dorsey in one lump sum an amount equal to the greater of (A) 12 months of the salary that he was receiving immediately prior to the termination or (B) 12 months of the salary that he was receiving immediately prior to the change of control; (ii) the Company shall pay to Mr. Dorsey in one lump sum (A) any accrued but unpaid bonus for the calendar year preceding his termination, to the extent that all criteria for such bonus have been met (with


the exception of the requirement that he be employed on the date the bonus is to be paid), plus (B) 100% of the average bonus paid by the Company to him for services during each of the three most recent fiscal years (or such shorter period of time during which he was eligible for a bonus) prior to the date of the termination; (iii) full acceleration of the vesting of all equity awards held by Mr. Dorsey at the time of the termination, including any options, restricted stock, RSUs or other awards, and (iv) reimbursement for the cost of continuation of health insurance benefits provided to him immediately prior to the termination pursuant to the terms of COBRA or other applicable law for a period continuing until the earlier of 12 months following the termination or the date upon which he is no longer eligible for such COBRA or other benefits under applicable law. In addition, the performance-based stock options granted to Mr. Dorsey in February 2015 will vest upon the occurrence of a change in control.
If he is terminated for cause at any time or if he voluntarily resigns under circumstances that do not constitute an involuntary termination, then Mr. Dorsey shall not be entitled to receive payment of any severance benefit or any continuation or acceleration of stock option vesting and all of his restricted stock awards shall remain subject to all applicable forfeiture provisions and transfer restrictions. He will receive payment for all salary accrued as of the date of termination of employment.
Response to 2015 Say on Pay Vote
In May 2015, we held a stockholder advisory vote on the compensation of our Named Executive Officers, commonly referred to as a say-on-pay vote. Our stockholders approved the compensation of our Named Executive Officers, with over 92% of stockholder votes cast in favor of our 2015 say-on-pay resolution (excluding abstentions and broker non-votes). As we have evaluated our compensation practices and talent needs since that time, we were mindful of the support our stockholders expressed for our compensation philosophy. As a result, the Compensation Committee has decided to generally retain our existing approach to executive compensation for our continuing executives, with an emphasis on short- and long-term incentive compensation that rewards our senior executives for corporate and individual performance, and a continuing emphasis on performance-based equity awards.
In addition, when determining how often to hold a stockholder advisory vote on executive compensation, the Board took into account the strong preference for an annual vote expressed by our stockholders at our 2011 annual meeting. Accordingly, the Board determined that we will hold an advisory stockholder vote on the compensation of our Named Executive Officers every year until the next say-on-pay frequency vote. Accordingly, we have included Proposal 3 related to a stockholder advisory vote on the compensation of our Named Executive Officers in this proxy statement.
Tax and Accounting Considerations
Deductibility of Executive Compensation. In making compensation decisions affecting our executive officers, the Compensation Committee may consider our ability to deduct under applicable federal corporate income tax law compensation payments made to executives. Specifically, the Compensation Committee may consider the requirements and impact of Section 162(m) of the Internal Revenue Code, which limits the tax deductibility to us of compensation in excess of $1.0 million in any year for certain executive officers, except for qualified “performance-based compensation” under the Section 162(m) rules. In setting compensation for executive officers, the deductibility of the compensation under Section 162(m) is only one factor that is weighed and compensation in excess of these limits may be granted, particularly while the Company is in a net operating loss position and is not currently paying income taxes.
Accounting for Share-Based Compensation. In accordance with the Financial Accounting Standards Board’s Accounting Standards Codification 718, we are required to estimate the value for each award of equity compensation at the measurement date using the fair value method and record an expense over the service period of the award. Accounting rules also require us to record cash compensation as an expense at the time the obligation is incurred.
Compensation Committee Report
The Company’s Compensation Committee has reviewed and discussed with management the Compensation Discussion and Analysis required by Item 407(e)(5) of Regulation S-K. Based on this review and discussion, the Compensation Committee recommended to the Board of Directors that the foregoing Compensation Discussion and Analysis be included in this Proxy Statement.
Submitted by the Compensation Committee of the Board of Directors:

Sandford D. Smith (Chair)
Wendell Wierenga, Ph.D.
Kleanthis G. Xanthopoulos, Ph.D.


Summary Compensation Table
The following table sets forth the compensation paid by us during the years ended December 31, 2015, 2014 and 2013 to (1) our principal executive officer during fiscal year 2015 and (2) the other two most highly paid executive officers who were serving as executive officers as of December 31, 2015:
Name and Position Year Salary 
Option
Awards (4)
 Non-Equity Incentive Plan Compensation (5) 
All Other
Compensation
 Total
Richard W. Pascoe, Chief Executive Officer, Secretary and Director (1) 2015 $473,200
 $342,413
 $88,555
 $13,124
 $917,292
 2014 $453,615
 $463,307
 $170,106
 $11,036
 $1,098,064
 2013 $335,342
 $1,427,400
 $142,521
 $10,597
 $1,915,860
Barbara Troupin, M.D., M.B.A., Senior Vice President, Chief Medical Officer (2) 2015 $325,000
 $
 $48,750
 $62,938
 $436,688
 2014 $1,250
 $242,335
 $375
 $
 $243,960
Brian T. Dorsey, Senior Vice President, Chief Development Officer (3) 2015 $310,000
 $
 $46,500
 $12,938
 $369,438
 2014 $11,923
 $236,132
 $3,577
 $54,331
 $305,963
(1)Mr. Pascoe joined the Company effective March 18, 2013. In 2015, all other compensation includes $10,600 for the Company’s matching and profit sharing contribution to the 401(k) plan and $2,524 in life insurance premiums.
(2)Dr. Troupin joined the Company effective December 12, 2014. Dr. Troupin’s all other compensation in 2015 includes $50,000 in relocation expenses, $10,600 for the Company’s matching and profit sharing contribution to the 401(k) plan and $2,338 in life insurance premiums.
(3)Mr. Dorsey joined the Company effective December 1, 2014. Mr. Dorsey’s all other compensation in 2015 includes $10,600 for the Company’s matching and profit sharing contribution to the 401(k) plan and $2,338 in life insurance premiums.
(4)Represents the grant-date fair value of equity awards, calculated in accordance with FASB ASC Topic 718, excluding the effect of estimated forfeitures. For a discussion of valuation assumptions for stock-based compensation, see note 8 to the Company’s audited financial statements filed with our annual report on Form 10-K for the year ended December 31, 2015. These figures do not reflect the amortized compensation expensewithout cause upon, or value received by the officer in the year indicated or that may be received by the officer with respect to such equity awards. With respect to the performance-based options granted to Mr. Pascoe, Dr. Troupin and Mr. Dorsey during 2015, the amounts in these columns include the grant-date fair value of such stock option awards based upon the probable outcome of such conditions, of which none were deemed probable. The full grant date fair value of such performance-based stock options, assuming full achievement of the performance conditions to which such stock options are subject, is as follows: Mr. Pascoe, $137,550; Dr. Troupin, $45,850; and Mr. Dorsey, $45,850.
(5)Represents the portion of the 2015 bonus paid in cash made to the above officers. For 2015, at the discretion of the Company’s Compensation Committee, RSUs were granted in satisfaction of one-half of the executives’ 2015 bonus awards. The RSUs were granted on March 15, 2016 under the Company’s 2012 Stock Long Term Incentive Plan. The number of RSUs issued to each executive was determined by dividing the portion of the annual bonus to be paid in the form of RSUs (Mr. Pascoe: $88,555; Dr. Troupin: $48,750; and Mr. Dorsey: $46,500) by the closing price of the Company’s common stock on the date of grant ($1.11). The RSUs will vest on February 15, 2017, subject to the executive’s continued employment with the Company through such vesting date, and therefore are not listed above as compensation during 2015.



Grants of Plan-Based Awards
The following table sets forth certain information regarding grants of plan-based awards to the Named Executive Officers during fiscal 2015:
    Estimated Future Payouts Under Non-Equity Incentive Plan Awards (1) Estimated Future Payouts Under Equity Incentive Plan Awards  
Option  Awards:
Number of
Securities
Underlying  Options
Granted (2)
 
Exercise Price
of Option
Awards
 
Grant Date  Fair
Value of Stock
and Option
Awards (3)
Name Grant Date Threshold ($) Target ($) Maximum ($) Target (#)    
Richard W. Pascoe 1/29/2015 $
 $236,600
 $
 
  300,000
 $1.43
 $342,413
 1/29/2015       45,000
(4) 
 $1.43
 $
 1/29/2015       60,000
(5) 
 $1.43
 $
 1/29/2015       45,000
(6) 
 $1.43
 $
Barbara Troupin, M.D., M.B.A. 1/29/2015 $
 $130,000
 $
 15,000
(4) 
 $1.43
 $
  1/29/2015       20,000
(5) 
 $1.43
 $
  1/29/2015       15,000
(6) 
 $1.43
 $
Brian T. Dorsey 1/29/2015 $
 $124,000
 $
 15,000
(4) 
 $1.43
 $
  1/29/2015       20,000
(5) 
 $1.43
 $
  1/29/2015       15,000
(6) 
 $1.43
 $
(1)Represents the target bonus awards under our annual incentive plan as described above under “Annual Cash Incentive.”
(2)Except as otherwise noted, all stock options have a term of ten years from the date of grant and vest over four years, with 25% of the shares subject to the options vest on the first anniversary of the date of grant and the remainder vest in 36 monthly thereafter. For a description of the accelerated vesting provisions applicable to the stock options granted to the Named Executive Officers, see “Payments Upon Termination or Change in Control” above.
(3)This column reflects the aggregate grant date fair value of equity awards granted in 2015 and calculated in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. For a discussion of valuation assumptions for stock-based compensation, see note 8 to the Company’s audited financial statements filed with our annual report on Form 10-K for the year ended December 31, 2015. These figures do not reflect the amortized compensation expense or value received by the officer in the year indicated or that may be received by the officer with respect to such equity awards. With respect to the performance-based options granted to Mr. Pascoe, Dr. Troupin, and Mr. Dorsey during 2015, the amounts in these columns include the grant-date fair value of such stock option awards based upon the probable outcome of such conditions. The full grant date fair value of such performance-based stock options, assuming full achievement of the performance conditions to which such stock options are subject, is set forth in the footnotes to the Summary Compensation Table above.
(4)Represents performance-based stock options that vest if the Last Patient Out in a Phase 3 development program occurs on or before December 31, 2017. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on December 31, 2017. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
(5)Represents performance-based stock options that vest if the Company successfully completes the fispemifene Phase 2b clinical trial in secondary hypogonadism by June 30, 2016, the results of which support moving into Phase 3 trials. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on June 30, 2016. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
(6)Represents performance-based stock options that vest if the filing of an NDA for RayVa occurs on or before December 31, 2017. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on December 31, 2017. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.


Outstanding Equity Awards as of December 31, 2015
The following table shows information regarding our outstanding equity awards as of December 31, 2015 for the Named Executive Officers:
  Option Awards (1)
Name Number of Securities Underlying Unexercised Options Exercisable (#) Number of Securities Underlying Unexercised Options Non-Exercisable (#) Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#) 
Option
Exercise
Price ($)
 
Option
Expiration
Date
Richard W. Pascoe 618,750
 281,250
 
 $2.51
 3/18/2023
  72,328
 85,480
 
 $2.36
 2/6/2024
  62,875
 25,875
(2)
 $2.38
 2/20/2024
  
 
 35,500
(3)$2.38
 2/20/2024
  
 300,000
 
 $1.43
 1/29/2025
  
��
 45,000
(4)$1.43
 1/29/2025
  
 
 60,000
(5)$1.43
 1/29/2025
  
 
 45,000
(6)$1.43
 1/29/2025
Barbara Troupin, M.D., M.B.A. 75,000
 225,000
 
 $1.16
 12/12/2024
  
 
 15,000
(4)$1.43
 1/29/2025
  
 
 20,000
(5)$1.43
 1/29/2025
  
 
 15,000
(6)$1.43
 1/29/2025
Brian T. Dorsey 75,000
 225,000
 
 $1.13
 12/1/2024
  
 
 15,000
(4)$1.43
 1/29/2025
  
 
 20,000
(5)$1.43
 1/29/2025
  
 
 15,000
(6)$1.43
 1/29/2025
(1)Except as otherwise noted, all stock options have a term of ten years from the date of grant and vest over four years, with 25% of the shares subject to the options vest on the first anniversary of the date of grant and the remainder vest in 36 monthly thereafter. For a description of the accelerated vesting provisions applicable to the stock options granted to the Named Executive Officer, see “Payments Upon Termination or Change in Control” above.
(2)
Pipeline Build. Represents performance-based stock options that vest based on the Company’s initiation of one or more Phase II or later clinical trials of assets approved by the Board (each, a “Qualifying Trial”) on or before December 31, 2015, as follows: (1) 25% of the underlying shares will vest upon the First Vesting Date (e.g., the enrollment of the first patient in the first Qualifying Trial) and 1/96th of the total number of shares subject to the option will vest monthly thereafter over a 24-month period so that the option will be vested and exercisable with respect to 50% of the total number of shares of stock underlying the stock option on the second anniversary of the First Vesting Date, provided that the executive does not have a termination of employment prior to any such vesting date, and (2) 25% of the underlying shares will vest upon the Second Vesting Date (e.g., the enrollment of the first patient in the second Qualifying Trial), and 1/96th of the total number of shares subject to the option will vest monthly thereafter over a 24-month period so that the option will be vested and exercisable with respect to 100% of the total number of shares of stock underlying the stock option on the second anniversary of the Second Vesting Date, provided that the executive does not have a termination of employment prior to any such vesting date. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control. In December 2014, the Compensation Committee determined that the “First Vesting Date” for the foregoing options had occurred as a result of the randomization and first dosing of the first RayVa Phase 2a patient in December 2014. As a result, a portion of the stock option award vested and a portion became subject solely to time-based vesting, as described above, on such date. In May 2015, the Compensation Committee determined that the “Second Vesting Date” for the foregoing options had occurred as a result of the randomization and first dosing of the first fispemifene patient in May 2015. As a result, a portion of the stock option award vested and a portion became subject solely to time-based vesting, as described above, on such date.
(3)
Room Temperature Product. Represents performance-based stock options that vest if the Company receives marketing authorization for a room temperature formulation or dispenser device for Vitaros by December 31, 2016. In the event such performance objective is achieved, the option shall vest with respect to 50% of the underlying shares on the date of receipt of such marketing authorization, and the remaining 50% will vest monthly over the next two years following the achievement


of such goal, provided that the executive does not have a termination of employment prior to any such vesting date. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
(4)
LPO in Phase 3 Program. Represents performance-based stock options that vest if the last patient out in a Phase 3 development program occurs on or before December 31, 2017. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on December 31, 2017. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
(5)
Fispemifene Phase 2b. Represents performance-based stock options that vest if the Company successfully completes the fispemifene Phase 2b clinical trial in secondary hypogonadism by June 30, 2016, the results of which support moving into Phase 3 trials. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on June 30, 2016. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
(6)
RayVa NDA. Represents performance-based stock options that vest if the Company is able to file an NDA for RayVa on or before December 31, 2017. In the event such performance objective is achieved, the option shall vest 100% of the underlying shares on December 31, 2017. Notwithstanding the foregoing, 100% of the shares subject to the option will accelerate and vest in full immediately prior to the occurrence of a change in control.
Option Exercises and Stock Vested
There were no stock awards that vested in fiscal 2015 held by the Named Executive Officers. None of our Named Executive Officers exercised options during fiscal 2015
Pension Benefits
We do not have a defined benefit plan. Our Named Executive Officers did not participate in, or otherwise receive any special benefits under, any pension or defined benefit retirement plan sponsored by us during fiscal 2015.
Non-Qualified Deferred Compensation
During 2015, our Named Executive Officers did not contribute to, or earn any amount with respect to, any defined contribution or other plan sponsored by us that provides for the deferral of compensation on a basis that is not tax-qualified.
Potential Payments upon Termination or Change of Control
The following table sets forth information regarding payments that would be made to Mr. Pascoe, Dr. Troupin and Mr. Dorsey in four scenarios: (1) upon an involuntary termination prior to a change in control; (2) upon termination as a result of the executive’s disability or death; (3) upon an involuntary termination within 12 months following, a change of control, we will pay to Mr. Golembiewski an amount equal to his then current monthly salary for a period of three months following his employment termination date as severance; provided that Mr. Golembiewski has (i) returned to us all our property in control;his possession, and (4) upon(ii) executed and delivered to us a change in control (without an involuntary termination). The table assumesgeneral release of all claims that the termination of employmenthe may have against us or change in control, as applicable, occurred on December 31, 2015 and does not include payments earned but not paid to the employee as of that date, such as accrued salary and unpaid vacation amounts. Base salary information is based on the salaries in effect as of December 31, 2015. The closing price per share of our Common Stock on The NASDAQ Capital Market on December 31, 2015 (which was the last business day of fiscal 2015) was $0.99.persons affiliated with us.


Name Benefit Type 
Payment in
the Event of an Involuntary
Termination
Prior to a Change in
Control
 
Payment in
the Event of a
Termination
by the
Company
following
Disability or Death
 
Payment in
the Event of an Involuntary
Termination Within 12 Months
Following a
Change in
Control
 
Payment in
the Event of a
Change in
Control
Without
Termination
Richard W. Pascoe Base Salary (1) $473,200
 $
 $473,200
 $
  Bonus $175,874
(2)$236,600
(3)$175,874
(2)$
  Benefits (4) $34,733
 $
 $34,733
 $
  Option Acceleration (5) $
 $
 $
 $
Barbara Troupin, M.D., M.B.A. Base Salary (1) $325,000
 $
 $325,000
 $
  Bonus $97,500
(2)$130,000
(3)$97,500
(2)$
  Benefits (4) $11,107
 $
 $11,107
 $
  Option Acceleration (5) $
 $
 $
 $
Brian T. Dorsey Base Salary (1) $310,000
 $
 $310,000
 $
  Bonus $93,000
(2)$124,000
(3)$93,000
(2)$
  Benefits (4) $34,733
 $
 $34,733
 $
  Option Acceleration (5) $
 $
 $
 $
19
(1)Reflects 12 months of base salary for each Named Executive Officer, payable in cash in a lump sum.
(2)For Mr. Pascoe, the amount reflects the average of his annual bonuses for 2013, 2014 and 2015 (with his 2013 annual bonus annualized for such purpose). For Dr. Troupin and Mr. Dorsey, the amount reflects the actual value of their bonuses for 2015. For 2015, the annual bonus amounts were calculated including the portion of the bonus paid in the form of RSUs. These amounts are payable in cash in a lump sum.
(3)Reflects actual annual bonus for 2015. These amounts are payable in cash in a lump sum.
(4)Reflects the value of 12 months of health benefits continuation. On April 13, 2016, Dr. Troupin and the Company entered into an employment transition agreement pursuant to which, among other things, Dr. Troupin agreed to receive six months of health benefits continuation.
(5)The value of accelerated vesting equals the difference (if positive) between the option exercise price and the last reported stock price for fiscal 2015 ($0.99), multiplied by the number of options that would have been accelerated upon a change of control occurring on December 31, 2015. Since all of the options held by our Named Executive Officers as of December 31, 2015 had exercise prices in excess of the closing price per share of our Common Stock on such date, no value is attributed to such acceleration in the table above.

TABLE OF CONTENTS

DIRECTOR COMPENSATION
We have adopted a non-employee director compensation policy pursuant to which our non-employee directors are eligible to receive cash and equity compensation. During 2015, each
On March 20, 2019, the Compensation Committee approved a non-employee director was entitled to receivecompensation policy governing the compensation for our non-employee directors (the “Non-Employee Director Compensation Policy”), authorizing the payment of an annual cash retainer of $40,000 with additional annual cash retainers for the chairs of our various Board committees in the following amounts: $15,000 for the chair of the Audit Committee, $12,000 for the chair of the Compensation Committee and $8,000 for the chair of the Corporate Governance/Nominating Committee. Additionally, non-chair members of these committees will receive additional annual cash retainers in the following amounts: $7,000 for members of the Audit Committee, $5,000 for members of the Compensation Committee and $3,000 for members of the Corporate Governance/Nominating Committee. The Chairman ofservice on the Board, is also entitled to receivean annual retainer of an additional annual cash retainer of $40,000 per year, payable in cash.
In February 2016, our Board approved an amendment tofor service as the equity component of our non-employee director compensation policy. Prior to such date, any non-employee director who was first elected to the Board was granted an option to purchase 50,000 shares of our common stock on the date of his or her initial election to the Board and thereafter on the first trading day of each calendar year, each non-employee director was eligible to receive an option to purchase 25,000 shares of common stock (or, in the case of our Chairman of the Board, an option to purchase 50,000 sharesannual retainer of common stock). Pursuant to$15,000 for service as the amendmentChair of the Audit Committee, an annual retainer of $7,000 for service as a member of the Audit Committee (excluding the Chair of the committee), an annual retainer of $12,000 for service as the Chair of the Compensation Committee, an annual retainer of $5,000 for service as a member of the Compensation Committee (excluding the Chair of the committee), an annual retainer of $8,000 for service as the Chair of the Corporate Governance/Nominating Committee and an annual retainer of $3,000 for service as a member of the Corporate Governance/Nominating Committee (excluding the Chair of the committee), and equity compensation in February 2016, any non-employee director who is first elected to the Board will be grantedform of an option to purchase 60,00024,000 shares of our common stockCommon Stock upon election or appointment to the Board (the “Initial Grants”) and an annual option to purchase 16,000 shares of our Common Stock (the “Annual Grants”). The Initial Grants vested at rate of one-third of the shares subject to the option on the one-year anniversary of the date of his or her initial election to the Boardgrant and the annual option grant was increased to 35,000 options (the annual grant in the case of our Chairman1/36th of the Board was unchanged and was also an option to purchase 50,000 shares of common stock prior to the amendment). Initial awards vest over three years in 36 equal monthly installments. Annual
awards vest over one year in 12 equal monthly installments, subject to the director’s continuing serviceoption on a monthly basis over the following 24 months. The Annual Grants will vest at a rate of 1/12th per month from the date of grant.
As previously disclosed, on March 15, 2021, the Compensation Committee revised our Board on those dates. All initial andNon-Employee Director Compensation Policy, effective as of April 1, 2021, to increase the cash portion of the annual awardsretainer payable to our non-employee directors will vest in full in the event of a change in control.
On April 5, 2016, our Board approved an amendmentand to the cash component of our non-employee director compensation policy. Prior to such date, the annual retainers were payable in cash. Pursuant to the amendment, the annual retainers shall be paid by the Company in quarterly installments as follows: (x) seventy-five percent (75%) of the retainer payable to a non-employee director for a calendar quarter shall be paid in cash within fifteen days following the end of such calendar quarter; and (y) twenty-five percent (25%) of the retainer payable to a non-employee director for a calendar quarter shall be paid in the form of fully vested shares of the Company’s common stock granted automatically on the last day of such calendar quarter pursuant to the Company’s 2012 Stock Long Term Incentive Plan (the “2012 Plan”), withincrease the number of shares of our Common Stock issuable to our non-employee directors pursuant to the Company’s common stockInitial Grant and the Annual Grants. Effective April 1, 2021, our non-employee directors are entitled to be issued calculated by dividingan annual retainer of $40,000 for service on the amount payable to such non-employee director divided byBoard, an annual retainer of an additional $40,000 for service as the closing price per shareChairman of the Company’s commonBoard, an annual retainer of $15,000 for service as the Chair of the Audit Committee, an annual retainer of $7,500 for service as a member of the Audit Committee (excluding the Chair of the committee), an annual retainer of $12,000 for service as the Chair of the Compensation Committee, an annual retainer of $6,000 for service as a member of the Compensation Committee (excluding the Chair of the committee), an annual retainer of $8,000 for service as the Chair of the Corporate Governance/Nominating Committee and an annual retainer of $4,000 for service as a member of the Corporate Governance/Nominating Committee (excluding the Chair of the committee), and equity compensation in the form of an option to purchase 42,000 shares of our Common Stock (subject to adjustment for stock splits, reverse stock splits, stock dividends and similar transactions) upon election or appointment to the Board and an annual option to purchase 35,000 shares of our Common Stock (subject to adjustment for stock splits, reverse stock splits, stock dividends and similar transactions). The Initial Grants will vest at rate of one-third of the shares subject to the option on the last dayone-year anniversary of the calendar quarterdate of grant and 1/36th of the shares subject to which such payment relates.the option on a monthly basis over the following 24 months. The Annual Grants will vest at a rate of 1/12th per month from the date of grant.
Non-Employee Director Compensation for 20152021
Below is a summary of the non-employee director compensation earnedpaid in fiscal 2015:2021:
Name
Cash
Compensation(1)
Option Grants(2)
Total
Richard W. Pascoe
$40,000
$18,035
$58,035
Brian Lian, Ph.D.
$67,377
$18,035
$85,412
Daniel J. O’Connor, J.D.
$60,753
$18,035
$78,788
Margaret Dalesandro, Ph.D.(3)
$17,214
$77,284
$94,498
Judith Dunn, Ph.D.(4)
$33,916
$18,035
$51,951
Name 
Cash
Compensation
 Option Grants (1)(2) Other Compensation Total
Kleanthis G. Xanthopoulos, Ph.D. $80,000
 $39,743
 $
 $119,743
Rusty Ray $56,250
 $19,872
 $
 $76,122
Deirdre Y. Gillespie, M.D. (3) $62,000
 $19,872
 $
 $81,872
Paul V. Maier $58,000
 $19,872
 $
 $77,872
Wendell Wierenga, Ph.D. $45,000
 $19,872
 $
 $64,872
Sandford D. Smith $43,750
 $19,872
 $
 $63,622
(1)
Includes the value of the annual retainers payable to our non-employee directors.
(1)(2)
This column reflectsRepresents the aggregate grant date fair value of equity awardsthe stock options granted in 2015 and calculated2021, computed in accordance with FASB ASC 718, excluding the effect of estimated forfeitures. For a discussion of valuation assumptions for stock-based compensation, see note 8 to the Company’s audited financial statements filed with our annual report on Form 10-K for the year ended December 31, 2015. These figures do not reflect the amortized compensation expense or value received by the director in the year indicated or that may be received by the director with respect to such equity awards.
(2)Topic 718. As of December 31, 2015,2021, each of our non-employee directors held stock options to purchase the following number of shares of our Common Stock: Dr. Xanthopoulos,common stock: Mr. Pascoe, options to purchase 132,00045,832 shares; Mr. Ray,Dr. Lian, options to purchase 82,00056,000 shares; Dr. Gillespie,Mr. O’Connor, options to purchase 82,00056,000 shares; Mr. Maier,and Dr. Dalesandro, options to purchase 91,000 shares; Dr. Wierenga, options to purchase 125,000 shares; and Mr. Smith, options to purchase 110,00042,000 shares.
(3)
Dr. GillespieDalesandro was appointed to our Board on September 1, 2021.
(4)
Dr. Dunn resigned from theour Board effective as of April 5, 2016.September 1, 2021.
20

Risk Management and Mitigation

In reviewing our compensation structure in fiscal 2015, the Compensation Committee also considered how the Company’s compensation policies may affect the Company’s risk profile and whether compensation policies and practices may encourage risk-taking by employees. More specifically, the Compensation Committee considered the general design philosophy of the Company’s policies for employees whose conduct would be most affected by incentives established by compensation policies. In considering these issues, the Compensation Committee concluded that the use of performance-based bonuses and long-term equity awards did not appear to create undue risks for the Company or encourage excessive risk-taking behavior on the part of Named Executive Officers.    
With respect to bonus awards, the amount of our Named Executive Officers’ individual awards depends exclusively on overall Company performance, which reduces the incentive for an individual to take undue risks in an effort to increase the amount of his or her bonus award for a particular year. The Company’s performance goals are reviewed and approved by the Compensation Committee in the early part of each fiscal year and are considered to be generally of the nature that would not encourage or reward excessive risk taking. Additionally, the Compensation Committee monitors the Company’s performance throughout the year and may intervene where actions by executive officers in pursuit of performance goal attainment appear to lead to undue risk.
With respect to equity awards, these awards typically vest over several years, meaning that long-term value creation, contrasted with short-term gain, presents the best opportunity for employees to profit from these awards. To the extent that performance-based equity awards are used, the events that trigger vesting are expected to be realized several years in the future. The Company has not historically used claw-back provisions or imposed holding periods for vested awards, although the Compensation Committee may consider whether such mechanisms might be appropriate in the future to mitigate risk. Additionally, the use of financial-based performance metrics to determine employee compensation may subject those payouts to claw-back penalties under the Dodd-Frank Act, to the extent that there is a subsequent restatement of the financial measure that was used to determine a payout.

TABLE OF CONTENTS

EQUITY COMPENSATION PLAN INFORMATION
Equity Compensation Plan Information
The following table gives information as of December 31, 20152021 about shares of our Common Stock that may be issued upon the exercise of options warrants and rightsor vesting of restricted stock units under all of our existing equity compensation plans:
Plan category
Number of securities to
be issued upon exercise
of outstanding options,
warrants and rights
(a)
Weighted-average
exercise price of
outstanding options,
warrants and rights
(b)(1)
Number of securities
remaining available for
future issuance under
equity compensation
plans (excluding
securities reflected in
column (a)(2)
Equity compensation plans approved by security holders(3)(4)
9,336,477
$2.67
1,405,011
Equity compensation plans not approved by security holders(5)
368,943
$1.37
2,111,814
Total
9,705,420
$2.60
3,516,825
Plan category 
Number of securities to
be issued upon exercise
of outstanding  options,
warrants and rights
(a)
   
Weighted-average
exercise price of
outstanding options,
warrants and rights
(b)
 
Number of securities
remaining available for
future issuance  under
equity compensation
plans (excluding
securities reflected in
column (a))
  
Equity compensation plans approved by security holders 4,053,605
 (1) $1.95
 2,534,252
 (2)
Equity compensation plans not approved by security holders 
    
 
   
Totals 4,053,605
    $1.95
 2,534,252
   
(1)
(1)
Consists of the weighted average exercise price of outstanding options outstanding as of December 31, 2015 under The NexMed Inc. Stock Option and Long Term Incentive Plan, The NexMed, Inc. 2006 Stock Incentive Plan (the “2006 Plan”) and the 2012 Plan.
2021, excluding Dr. Mehra’s PRSU since it does not have an exercise price.
(2)
(2)
Consists entirely of 1,362,832 and 1,171,420 shares of Common Stock that remain available for future issuance under the Inducement Plan, the 2020 Employee Stock Purchase Plan (the “ESPP”) and the Amended and Restated 2012 Plan as of December 31, 2015,2021.
(3)
Consists of options outstanding as of December 31, 2021 under theAmended and Restated 2012 Plan and the NexMed, Inc. 2006 Stock Incentive Plan, respectively.and shares of Common Stock that remain available for future issuance under the ESPP, including the PRSU granted to Dr. Mehra in March 2021, which was outstanding as of December 31, 2021, but voluntarily forfeited by Dr. Mehra and cancelled on March 8, 2022.
(4)
The number of shares of Common Stock available for issuance under the Amended and Restated 2012 Plan will increase automatically on January 1st of each year, beginning January 1, 2020 and ending on (and including) January 1, 2029 by the lesser of (a) 4% of the number of shares of Common Stock issued and outstanding on a fully-diluted basis as of the close of business on the immediately preceding December 31, and (b) a number of shares of Common Stock set by the Board on or prior to each such January 1. On January 1, 2021 and each January 1 thereafter through January 1, 2030, the number of shares available for issuance under the ESPP shall be cumulatively increased by the lesser of (i) 1% of the number of shares of Common Stock issued and outstanding on the immediately preceding December 31, and (ii) such number of shares as determined by the Board or the Compensation Committee.
(5)
Consists of the Inducement Plan and the Seelos Therapeutics, Inc. 2016 Equity Incentive Plan.
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REPORT OF THE AUDIT COMMITTEE
The Audit Committee evaluates auditor performance, manages relations with the Company’s independent registered public accounting firm and evaluates policies and procedures relating to internal control systems. The Audit Committee operates under a written Audit Committee Charter that has been adopted by the Board, a copy of which is available on the Company’s website at www.apricusbio.comwww.seelostherapeutics.com/corporate-governance/. All members of the Audit Committee currently meet the independence and qualification standards for Audit Committee membership set forth in the listing standards provided by NASDAQNasdaq Rules and applicable SEC rules.
The Audit Committee members are not professional accountants or auditors. The members’ functions are not intended to duplicate or to certify the activities of management and the independent registered public accounting firm. The Audit Committee serves a board-level oversight role in which it provides advice, counsel and direction to management and the auditors on the basis of the information it receives, discussions with management and the auditors, and the experience of the Audit Committee’s members in business, financial and accounting matters.
The Audit Committee oversees the Company’s financial reporting process on behalf of the Board. The Company’s management has the primary responsibility for the financial statements and reporting process, including the Company’s system of internal controls. In fulfilling its oversight responsibilities, the Audit Committee reviewed and discussed with management the audited financial statements included in the Annual Report on Form 10-K for the fiscal year ended December 31, 2015.2021. This review included a discussion of the quality and the acceptability of the Company’s financial reporting, including the nature and extent of disclosures in the financial statements and the accompanying notes. The Audit Committee also reviewed the progress and results of the testing of the design and effectiveness of itsthe Company’s internal controls over financial reporting pursuant to Section 404 of the Sarbanes-Oxley Act of 2002.
Throughout the year, the Audit Committee monitors matters related to the independence of the Company’s independent registered public accounting firm. As part of its monitoring activities, the Audit Committee reviews the relationships between the independent registered public accounting firm and the Company. After reviewing the relationships and discussing them with both management and the Company’s independent registered public accounting firm, the Audit Committee discussed the independent registered public accounting firm’s overall relationship with the Company, as well as its objectivity and independence. Based on its review, the Audit Committee is satisfied with the auditors’independent registered public accounting firm’s independence.

The Audit Committee has received the written disclosures and the letter from the Company’s independent registered public accounting firm also has confirmed to the Committee in writing, as required by applicable requirements of the Public Company Accounting Oversight Board (the “PCAOB”PCAOB) regarding itsindependent registered public accounting firm’s communications with the Audit Committee concerning independence, that, in its professional judgment, it isand has discussed with the Company’s independent ofregistered public accounting firm the Company under all relevant professional and regulatory standards.independent registered public accounting firm’s independence.
The Audit Committee also reviewed with the Company’s independent registered public accounting firm, which is responsible for expressing an opinion on the conformity of the audited financial statements with accounting principles generally accepted in the United States of America, their judgments as to the quality and the acceptability of the Company’s financial reporting and such other matters as are required to be discussed with the Audit Committee under generally accepted auditing standards, including Statement on Auditing Standards No. 16, as adopted by the PCAOB.applicable requirements of the PCAOB and the SEC.
In addition to the matters specified above, the Audit Committee discussed with the Company’s independent registered public accounting firm the overall scope, plans and estimated costs of their audit. The Audit Committee met with the independent registered public accounting firm periodically, with and without management present, to discuss the results of the independent registered public accounting firm’s examinations, the overall quality of the Company’s financial reporting and the independent registered public accounting firm’s reviews of the quarterly financial statements, and drafts of the quarterly and annual reports.
In reliance
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Based on the reviews and discussions referred to above, the Audit Committee recommended to the Board that the Company’s audited financial statements should be included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2015.2021.
Submitted by the Audit Committee of the Board of Directors
Paul V. Maier
Brian Lian, Ph.D. (Chair)
Deirdre Y. Gillespie, M.D.
Margaret Dalesandro, Ph.D.
Rusty Ray
Richard W. Pascoe
Daniel J. O’Connor*
*
Served on the Audit Committee until February 2022.
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DOCUMENTS INCORPORATED BY REFERENCE

The SEC allows us to “incorporate by reference” information into this document. This means that the Company can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is considered to be a part of this document, except for any information that is superseded by information that is included directly in this document or in any other subsequently filed document that also is incorporated by reference herein.
This document incorporates by reference our Annual Report on Form 10-K for the fiscal year ended December 31, 2015, which was filed previously with the SEC and contains important information about the Company and its financial condition, including information contained in our such annual report under the captions “Financial Statements and Supplementary Data,” “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” “Changes in and Disagreements with Accountants on Accounting and Financial Disclosure,” and “Quantitative and Qualitative Disclosures about Market Risk.”
The Company will amend this proxy statement to include or incorporate by reference any additional documents that the Company may file with the Securities and Exchange Commission under Section 13(a), 13(e), 14, or 15(d) of the Exchange Act after the date of this document to the extent required to fulfill our disclosure obligations under the Exchange Act.
Copies of the 2015 Annual Report accompany this proxy statement. This proxy statement and the Company’s 2015 Annual Report are available on the Internet at www.apricusbio.com. These documents are also included in our SEC filings, which you can access electronically at the SEC’s website at http://www.sec.gov.

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CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS
Review and Approval of Transactions with Related Persons
Our Board has adopted a written policy and procedures for review, approval and monitoring of transactions involving our Companyus and “related persons” (directors, director nominees, executive officers and stockholders owning 5% or greater of our outstanding Common Stock and immediate family members of any of the foregoing). The policy covers any related person transaction that meets the minimum threshold for disclosure in our proxy statement under our policy addressing the relevant SEC rules (generally, transactions involving amounts exceeding the lesser of $120,000 in which a related person has a direct or indirect material interest). Related person transactions must be approved by the Board or by the Audit Committee of the Board consisting solely of independent directors, which will approve the transaction if they determine that it is in our best interests. The Board or the Audit Committee will periodically monitor the transaction to ensure that there are no changes that would render it advisable for us to amend or terminate the transaction.
Transactions with Related Persons
The severance arrangementsemployment agreements we have entered into with each of our executive officersNamed Executive Officers provide for severance benefits in specified circumstances, as well as benefits in connection with a change in control. See “Payments Uponthe section of this Proxy Statement titled “Executive Compensation - Payments upon Termination or Change In Control.”in Control” for additional information about these arrangements.
Our Bylaws provide that we will indemnify each of our directors and officers to the fullest extent permitted by the laws of the State of Nevada. Further, we have entered into indemnification agreements with each of our directors and officers, and we have purchased a policy of directors’ and officers’ liability insurance that insures our directors and officers against the cost of defense, settlement or payment of a judgment under certain circumstances.
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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS
The following table sets forth information with respect to the beneficial ownership, as of the Record Date,March 25, 2022, of Common Stock by (a) each of our Named Executive Officers and current directors individually, (b) our current directors and executive officers as a group and (c) each holder of more than 5% of the Company’sour outstanding Common Stock.
Beneficial ownership and percentage ownership are determined in accordance with the Rule 13d-3 of the Exchange Act. Under these rules, shares of common stockCommon Stock issuable under stock options or warrants that are exercisable within 60 days of the Record DateMarch 25, 2022 are deemed outstanding for the purpose of computing the percentage ownership of the person holding the options or warrant(s), but are not deemed outstanding for the purpose of computing the percentage ownership of any other person.
Unless otherwise indicated and subject to applicable community property laws, to our knowledge, each stockholder named in the following table possesses sole voting and investment power over their shares of Common Stock, except for those jointly owned with that person’s spouse.


Name and Address of Beneficial Owner (1) Number of Shares Beneficially Owned Percentage of Class (%) (2)
 
Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830 (3) 21,203,577
 30.95%
Aspire Capital Fund, LLC, 155 North Wacker Drive, Suite 1600, Chicago, IL 60606 (4) 6,102,228
 9.68%
     
Directors and Executive Officers    
Richard W. Pascoe (5) 1,029,787
 1.64%
Kleanthis G. Xanthopoulos (6) 213,022
 *
Rusty Ray (7) 131,112
 *
Deirdre Y. Gillespie, M.D. (8) 122,433
 *
Brian T. Dorsey (9) 116,250
 *
Wendell Wierenga, Ph.D. (10) 112,352
 *
Barbara Troupin, M.D., M.B.A. (11) 106,250
 *
Paul V. Maier (12) 105,583
 *
Sandford D. Smith (13) 101,870
 
*


All current executive officers and directors as a group (nine persons) (14) 2,038,659
 3.21%
Name and Address of Beneficial Owner
Number of Shares
Beneficially Owned
Percentage of
Class (%)(1)
BlackRock, Inc.(2)
6,563,054
6.2%
 
 
 
Directors and Named Executive Officer(3)
 
 
Raj Mehra, Ph.D.(4)
4,868,677
4.5%
Michael Golembiewski(5)
392,617
*
Daniel J. O’Connor, J.D., Director(6)
83,666
*
Brian Lian, Ph.D., Director(6)
83,666
*
Richard W. Pascoe, Director(7)
78,737
*
Margaret Dalesandro, Ph.D., Director(6)
11,666
*
All current executive officers and directors as a group (six persons)(8)
5,519,029
5.1%
*
*LessDenotes less than one percent.
(1)
Percentage ownership is calculated based on a total of 105,590,773 shares of Common Stock issued and outstanding as of March 25, 2022.
(2)
BlackRock, Inc. (“BlackRock”) filed a Schedule 13G on February 4, 2022, reporting that it had sole voting power with respect to 6,416,023 shares, sole dispositive power with respect to 6,563,054 shares and beneficial ownership of an aggregate of 6,563,054 shares in its capacity as a parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G) under the Exchange Act. BlackRock’s address is 55 East 52nd Street, New York, New York 10055.
(3)
Unless otherwise indicated, the address for each of our executive officers and directors is c/o 11975 El Camino Real, Suite 300 San Diego, California, 92130.Park Avenue, 2nd Floor, New York, NY 10022.
(4)
(2)Percentage ownership is calculated based on a total of 61,778,121Represents (i) 3,013,262 shares of Common Stock issuedheld directly by Dr. Mehra, and outstanding as of the Record Date.
(3)
Represents(ii) 1,855,415 shares of Common Stock beneficially owned by Sarissa Capital Management LP (“Sarissa Management”) at March 3, 2016, as indicated in the entity’s Schedule 13D/A filed with the SEC on March 7, 2016. The shares of Common Stock are owned by Sarissa Management, Alexander J. Denner, the Chief Investment Officer of Sarissa Management, Sarissa Capital Offshore Master Fund LP and Sarissa Capital Domestic Fund LP. Sarissa Management’s beneficial ownership includes warrants to purchase up to 6,724,525 shares.
(4)Represents shares of Common Stock beneficially owned by Aspire Capital Fund, LLC at February 13, 2015, as indicated in the entity’s Schedule 13G/A filed with the SEC on that date, plus 2,556,819 shares and 1,278,409 warrant shares delivered pursuant to a certain subscription agreement entered into by and between the Company and Aspire Capital Fund, LLC, dated January 12, 2016. Aspire’s beneficial ownership includes warrants to purchase up to 1,278,409 shares.
(5)Includes 965,287 shares issuable upon exercise of stock options and 17,500 shares issuable upon exercise of warrantsthat are exercisable within 60 days of the Record Date.March 25, 2022.
(5)
(6)Includes 148,666Represents (i) 78,487 shares of Common Stock held directly by Mr. Golembiewski, and (ii) 314,130 shares of Common Stock issuable upon exercise of stock options that are exercisable within 60 days of the Record Date and 64,356March 25, 2022.
(6)
Comprised solely of shares of Common Stock held jointly in a trust.
(7)Includes 90,333 shares issuable upon exercise of stock options and 2,500that are exercisable within 60 days of March 25, 2022.
(7)
Represents (i) 5,180 shares of Common Stock held directly by Mr. Pascoe, (ii) 59 shares of Common Stock issuable upon exercise of warrants that are exercisable within 60 days of the Record Date.
(8)Includes 107,000March 25, 2022, and (iii) 73,498 shares of Common Stock issuable upon exercise of stock options that are exercisable within 60 days of the Record Date.March 25, 2022.
(8)
(9)Includes 106,250Comprised of shares issuable upon exercisebeneficially owned by each of stock options exercisable within 60 days of the Record Date.our directors and current executive officers.
(10)Includes 87,502 shares issuable upon exercise of stock options exercisable within 60 days of the Record Date.
(11)Includes 106,250 shares issuable upon exercise of stock options exercisable within 60 days of the Record Date and 24,850 shares of Common Stock held jointly in a trust.
(12)Includes 99,333 shares issuable upon exercise of stock options exercisable within 60 days of the Record Date.
(13)Includes 70,520 shares issuable upon exercise of stock options exercisable within 60 days of the Record Date.
(14)Includes 1,781,141 shares issuable upon exercise of stock options and 20,000 shares issuable upon exercise of warrants exercisable within 60 days of the Record Date.
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SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
Section 16(a) of the Securities Exchange Act requires our executive officers, directors and persons who beneficially own greater than 10% of a registered class of its equity securities to file certain reports with the SEC with respect to ownership and changes in ownership of the Common Stock and our other equity securities.


To the Company’s knowledge, based solely on our review of the copies of such reports filed with the SEC, our officers, directors and greater than 10% stockholders timely complied with these Section 16(a) filing requirements during the fiscal year ended December 31, 2015, except that each of our non-employee directors filed one late Form 4 on January 26, 2015, in connection with the annual stock option grants as of the first trading day of 2015.
STOCKHOLDER PROPOSALS
Stockholder proposals will be considered for inclusion in the Proxy Statement for the 20172023 annual meeting in accordance with Rule 14a-8 under the Exchange Act, if they are received by theour Company’s Secretary, on or before December 9, 2016.16, 2022.
Stockholders who intend to present a proposal or director nominee at the 20172023 annual meeting of stockholders without inclusion of such proposal in our proxy materials for the 20172023 annual meeting are required to provide notice of such proposal within the time periods and in the manner set forth in our bylawsBylaws and the Charter of the Corporate Governance/Nominating Committee, a copy of which is available on our corporate website at www.apricusbio.comwww.seelostherapeutics.com/corporate-governance/. Proposals of business to be conducted at the 20172023 annual meeting other than nominations for election of directors, must be submitted between February 19, 20172023 and March 21, 2017,2023, which are 90 and 60 days prior to the first anniversary of the 20162022 annual meeting, provided, however, that in the event that the date of the pending annual meeting is advanced by more than 30 days or delayed by more than 60 days from such anniversary date, such submission must be delivered not earlier than the 90th day prior to such pending annual meeting and not later than the close of business on the later of the 60th day prior to such pending annual meeting or the 10th day following the day on which a public announcement of the date of such annual meeting is first made. Director nominees must be submitted between December 9, 2016 and January 8, 2017, which are 120 and 90 days prior to the anniversary of the mailing date of the proxy materials for the 2016 Annual Meeting, provided that if the date of the 2017 annual meeting is advanced by more than 30 days or delayed by more than 60 days, notice must be delivered within 10 days after announcement of the 2017 annual meeting date is first made. We reserve the right to reject, rule out of order, or take other appropriate action with respect to any proposal that does not comply with these and other applicable requirements.
Proposals and notices of intention to present proposals at the 20172023 annual meeting should be addressed to the Secretary of Apricus Biosciences,Seelos Therapeutics, Inc., 11975 El Camino Real, Suite 300 San Diego, California, 92130.Park Avenue, 2nd Floor, New York, NY 10022.
DELIVERY OF PROXY MATERIALS
In some cases, only one copy of this Proxy Statement or our 20162021 Annual Report is being delivered to multiple stockholders sharing an address unless we have received contrary instructions from one or more of the stockholders. We will deliver promptly, upon written or oral request, a separate copy of this Proxy Statement or such Annual Report to a stockholder at a shared address to which a single copy of the document was delivered. Stockholders sharing an address who are receiving multiple copies of proxy statements or annual reports may also request delivery of a single copy. To request separate or multiple delivery of these materials now or in the future, a stockholder may submit a written request to the Secretary of Apricus Biosciences,Seelos Therapeutics, Inc., 11975 El Camino Real, Suite 300 San Diego, California, 92130Park Avenue, 2nd Floor, New York, New York 10022 or an oral request at (858) 222-8041.call (646) 293-2100. Please make your request no later than May 1, 20162022 to facilitate timely delivery.
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WHERE YOU CAN FIND ADDITIONAL INFORMATION
We have filed reports, proxy statements and other information with the SEC. You may read and copy any document we file with the SEC at the SEC’s Public Reference Room at 100 F Street, N.W., Washington, D.C. 20549. You may obtain information on the Public Reference Room by calling the SEC at 1-800-SEC-0330. The SEC maintains a website that contains the reports, proxy statements and other information we file electronically with the SEC. The address of the SEC website is http://www.sec.gov.
You may request, and we will provide at no cost, a copy of these filings, including any exhibits to such filings, by writing or telephoning us at the following address: Secretary of Apricus Biosciences,Seelos Therapeutics, Inc., 11975 El Camino Real, Suite 300 San Diego, California, 92130 or an oral request at (858) 222-8041.Park Avenue, 2nd Floor, New York, New York 10022. You may also access these filings on our website at our web site under the investor relations link at www.apricusbio.comwww.seelostherapeutics.com/sec-filings/.
OTHER MATTERS
The Board knows of no other business that will be presented at the Annual Meeting. If any other business is properly brought before the Annual Meeting, it is intended that proxies in the enclosed form will be voted in respect thereof in accordance with the judgment of the persons voting the proxies.
It is important that proxies be returned promptly and that your shares are represented. Stockholders are urged to vote via the Internet (www.proxyvote.com), by telephone (1-800-690-6903) or by executing and promptly returning the accompanying proxy card in the enclosed envelope. The deadline to vote by Internet or telephone is 11:59 P.M. Eastern Time on Thursday, May 19, 2016.2022.
By Order of the Board of Directors,

Richard W. Pascoe
Raj Mehra, Ph.D.
Secretary
Chief Executive Officer
April 19, 2016
San Diego, California
April 12, 2022
New York, New York



[FORM OF PROXY-FRONT SIDE OF TOP PORTION]
You are cordially invited to attend our
2016 Annual Meeting of Stockholders,
to be held at Latham & Watkins LLP
12670 High Bluff Drive, San Diego, California 92130
at 8:00 a.m., local time, on Friday, May 20, 2016.
Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:
The Notice, Proxy Statement, Proxy Card and Form 10-K are available at www.proxyvote.com.
[FORM OF PROXY-REVERSE SIDE OF TOP PORTION]
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PROXYPROXY
APRICUS BIOSCIENCES, INC.
THIS PROXY IS SOLICITED BY THE BOARD OF DIRECTORS
The undersigned hereby appoint(s) Richard W. Pascoe, the lawful attorney and proxy of the undersigned, with full power of substitution, for and in the name, place and stead of the undersigned to attend the Annual Meeting of Stockholders of Apricus Biosciences, Inc. to be held at Latham & Watkins LLP, 12670 High Bluff Drive, San Diego, California 92130 on Friday, May 20, 2016 at 8:00 a.m., local time, and any adjournment(s) thereof, with all powers the undersigned would possess if personally present, and to vote the number of shares the undersigned would be entitled to vote if personally present.
In accordance with his discretion, said attorney and proxy is authorized to vote upon such other matters or proposals not known at the time of solicitation of this proxy, which may properly come before the meeting.
This proxy when properly executed will be voted in the manner described herein by the undersigned stockholder. If no instructions are given, the shares will be voted FOR the election of the nominees for directors named on the reverse side and FOR Proposal Nos. 2 and 3. Any prior proxy is hereby revoked.

Address Changes/Comments:
(If you noted any Address Changes/Comments above, please mark corresponding box on the reverse side.)
Continued and to be signed on reverse side
The Board of Directors recommends a vote FOR the election of the nominees for directors named below and FOR Proposal Nos. 2 and 3.
PROPOSAL NO. 1: Election of Class I Directors

Class I Directors
1) Kleanthis G. Xanthopoulos, Ph.D.
2) Paul V. Maier


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FOR ALLWITHHOLD ALLFOR ALL EXCEPT
To withhold authority to vote for any individual nominee, mark “For All Except” and write the number of such nominee on the line below.
PROPOSAL NO. 2: To ratify the selection of BDO USA, LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2016.
FORAGAINSTABSTAIN
PROPOSAL NO. 3: To approve, on an advisory basis, the compensation paid to the Company’s Named Executive Officers, as disclosed pursuant to Item 402 of Regulation S-K, including the Compensation Discussion and Analysis, compensation tables and narrative discussion.
FORAGAINSTABSTAIN


For address changes and/or comments, please check this box and write them on the back where indicated.
Please sign exactly as your name(s) appear(s) hereon.
When shares are held by joint tenants, both should sign.
When signing as attorney, executor, administrator, trustee or corporation, please sign in full corporate name by president or other authorized person. If a partnership, please sign in partnership name by authorized person.

Signature (PLEASE SIGN WITHIN BOX)DateSignature (Joint Owners)Date

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FORM OF PROXY DETACHABLE PROXY CARD
APRICUS BIOSCIENCES, INC.
11975 El Camino Real, Suite 300
San Diego, CA 92130
There are three ways to vote your Proxy.
Your telephone or Internet vote authorizes the Named Proxies to vote your shares in the same manner as if you marked, signed and returned your proxy card.
VOTE BY PHONE – TOLL FREE – 1-800-690-6903 – QUICK *** EASY *** IMMEDIATE
Use any touch-tone telephone to vote your proxy 24 hours a day, 7 days a week, until 11:59 P.M. Eastern Time on Thursday, May 19, 2016. Have your proxy card in hand when you call and then follow the instructions.
VOTE BY INTERNET – www.proxyvote.com – QUICK *** EASY *** IMMEDIATE
Use the Internet to transmit your voting instructions and for electronic delivery of information up until 11:59 P.M. Eastern Time on Thursday, May 19, 2016. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.
VOTE BY MAIL
Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Apricus Biosciences, Inc., c/o Broadridge, 51 Mercedes Way, Edgewood NY 11717.
ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALS


If you would like to reduce the costs incurred by our Company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.
If you vote by Phone or Internet, please do not mail your Proxy Card.
Please detach here

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